Human N-type calcium channel isoform and uses thereof

Details Human N-type calcium channel isoform and uses thereof Human N-type calcium channel isoform and uses thereof

2006-03-28

2006-03-28

McGarry, Sean (Department: 1635)

Chemistry: molecular biology and microbiology

Vector, per se

C435S006120, C435S325000, C435S252300, C536S023100, C536S023500, C536S024300

Reexamination Certificate

active

07018832

ABSTRACT:
The invention pertains to a human N-type calcium channel isoform, hα1B+SFVG, which is involved in central nervous system signaling, and nucleic acids relating thereto. The present invention also includes fragments and biologically functional variants of the human hα1B+SFVGchannel. Also included are human N-type calcium channel hα1B+SFVGsubunit inhibitors which inhibit human N-type calcium channel hα1B+SFVGsubunit activity by inhibiting the expression or function of human N-type calcium channel hα1B+SFVGsubunit. The invention further relates to methods of using such nucleic acids, polypeptides, and inhibitors in the treatment and/or diagnosis of disease, such as in methods for treating stroke, pain, e.g., neuropathic pain, and traumatic brain injury.

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