Human N-acetylneuraminate lyase

Details Human N-acetylneuraminate lyase Human N-acetylneuraminate lyase

1998-02-20

1999-10-05

Prouty, Rebecca E.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Lyase

435 6, 435 691, 4353201, 435325, 536 231, 536 232, 536 235, C12N 988, C12N 1563, C12N 1585, C12Q 168

Patent

active

059623020

ABSTRACT:
The invention provides a human N-acetylneuraminate lyase (HNANL) and polynucleotides which identify and encode HNANL. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of HNANL.

REFERENCES:
Vimr and Troy, "Regulation of Sialic Acid Metabolism in Escherichia coli: Role of N-Acylneuraminate Pyruvate-Lyase", J. Bacteriol., 164:854-860 (1985).
Meysick, K.C. et al., "Molecular characterization and expression of a N-acetylneuraminate lyase gene from Trichomonas vaginalis", Mol. Biochem. Parasitol., 76:289-292 (1996) (GI 1016805, GI 1016806).
Misasi et al., "Gangliosides and Autoimmune Diabetes", Diabetes Metab. Rev., 13:163-179 (1997).
Ohta, Y. et al., GenBank Sequence Database (Accession X03345), National Center for Biotechnology Information: National Library of Medicine, Bethesda, Maryland 20849 (GI 42130, GI 42131) (1993).
Meysick, K.C. et al., GenBank Sequence Database (Accession U35878), National Center for Biotechnology Information: National Library of Medicine, Bethesda, Maryland 20849 (GI 1016805, GI 1016806) (1997).
Ohta, Y. et al., "Complete nucleotide sequence of the E. coli N-acetylneuraminate lyase", Nucleic Acid Res., 13:8843-8852 (1985) (GI 42130, GI 42131).
Hillier, L. et al., Genbank, Accession No. W79930, Oct. 1996.
Lawrence, M. et al., J. Mol. Biol., vol. 266, No. 2, pp. 381-399, Feb. 1997 .

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