Human N-acetylneuraminate lyase

Details Human N-acetylneuraminate lyase Human N-acetylneuraminate lyase

1999-02-01

2000-02-29

Achutamurthy, Ponnathapu

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Lyase

C12N 988

Patent

active

060308249

ABSTRACT:
The invention provides a human N-acetylneuraminate lyase (HNANL) and polynucleotides which identify and encode HNANL. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of HNANL.

REFERENCES:
Hillier et al., Genbank Database, Accession No. W79930, Oct. 1998.
Lawrence, M. et al., J. Mol. Biol., vol.266, No. 2, pp. 381-399, Feb. 1997.
Vimr and Troy, Regulation of Sialic Acid Metabolism in Escherichia coli:Role of N-Acylneuraminate Pyruvate-Layase, J. Bacteriol., 164:854-860 (1985).
Meysick, K.C. et al., Molecular characterization and expression of a N-acetylneuraminate lyase gene from Trichomonas vaginalis, Mol. Biochem. Parasitol., 76:289-292 (1996) (GI 1016805, GI 10106806).
Misasi et al., Gangliosides and Autoimmune Diabetes, Diabetes Metab. Rev., 13:163-179 (1997).
Ohta, Y. et al., GenBank Sequence Database (Accession X03345), National Center for Biotechnology Information: National Library of Medicine, Bethesda, Maryland 20849 (GI 42130, GI 42131).
Meysick, K.C. et al., GenBank Sequence Database (Accession U35878), National Center for Biotechnology Information: National Library of Medicine, Bethesda, Maryland 20849 (GI 1016805, GI 10106806).
Ohta, Y. et al., Complete nucleotide sequence of the E. coli N-acetylneuraminate lyase, Nucleic Acid Res., 13:8843-8852 (1985) (GI 42130, GI 42131).

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