Human myotrophin

Details Human myotrophin Human myotrophin

1997-09-19

2000-11-28

Johnson, Nancy A

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

435 6, 435 691, 4353201, 435325, 4352542, 536 235, 536 231, 536 2431, 514 44, C07H 2104, C12N 121, C12N 1512, C12Q 168

Patent

active

061534234

ABSTRACT:
The invention provides a human myotrophin (MYO1) and polynucleotides which identify and encode MYO1. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of MYO1.

REFERENCES:
New England Biolabs 1993/94 Catalog pp. 91 and 116-117.
Taoka, J. Biol. Chem 269:9946, 1994.
Pennica, Gene 158: 305, 1995.
Sivasubramanian, J. Biol Chem 271: 2812, 1996.
Gene Bank Accession No. 021661, Apr. 25, 1996.
Riechmann, V. and Sablitzky, F., "Mutually Exclusive Expression of Two Dominant-Negative Helix (dnHLH) Genes, Id4 and Id3, in the Developing Brain of the Mouse Suggests Distinct Regulatory Roles of These dnHLH Proteins during Cellular Proliferation and Differentiation of the Nervous System,"Cell Growth & Differentiation, 6:837-843 (1995).
Blackwell, T. and Christman, J.W., "The Role of Nuclear Factor-kB in Cytokine Gene Regulation,"Am. J. Respir. Cell Mol. Biol., 17:3-9 (1997).
O'Neill, L. and Kaltschmidt, C., "NF-kB: a crucial transcription factor for glial and neuronal cell function,"TINS, 20(6) :252-258 (1997).
Boucier, T., et al., "The Nuclear Factor k-B Signaling Pathway Participates in Dysregulation of Vascular Smooth Muscle Cells in Vitroand in Human Atherosclerosis,"J. Biol. Chem., 272(25) :15817-15824 (1997).
Jourd'heuil, D., et al., "Oxidant-regulation of Gene Expression in the Chronically Inflamed Intestine,"Keio J. Med., 46:10-15 (1997).
Sen, S., et al., "Myotrophin: Purification of a Novel Peptide from Spontaneously Hypertensive Rat Heart that Influences Myocardial Growth,"J. Biol. Chem., 265(27) :16635-16643 (1990).
Sivasubramanian, N., et al., "Cardiac Myotrophin Exhibits rel/NF-kB Interacting Activity in Vitro,"J. Biol., Chem., 271(5) :2812-2816 (1996) (GI 903891 and GI 903892).
Taoka, M., et al., "Murine Cerebellar Neurons Express a Novel Gene Encoding a Protein Related to Cell and Control Cycle Cell Fate Determination Proteins,"J. Biol. Chem., 269(13): 9946-9951 (1994).
Mitsubishi Kasei Corp., Japanese Publication No. J041938991A (Gene Seq Report only), Nov. 27, 1990.
Sil, P., et al., "Myotrophin Human Cardiomyopathic Heart,"Circulation Research, 73(1) :98-108 (1993).
Sivasubramanian, N., et al., (GI 903892) GenBank Sequence Database (Accession No. U21661), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894.
Sivasubramanian, N., et al., (GI 903891) GenBank Sequence Database (Accession No. U21661), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894.

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