Human myeloperoxidase and its therapeutic application

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Oxidoreductase

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435 691, 435189, 4352523, 4355201, 435 14, 435 32, 435 66, 435 70, 424 944, 424417, 424418, 536 232, C12N 908, C12N 1553, A61K 3750, A01N 2528

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054609615

ABSTRACT:
A substantially pure recombinant human myeloperoxidase heme-containing precursor, comprising a glycoprotein of 84 KD with the amino acid sequence coded for by the nucleotide sequence from 145 to 2235 corresponding to codons 49 to 745 in phase after the first methionine codon in FIG. 1 produced by culturing prokaryotic or eukaryotic cells transformed by a vector for the expression of human myeloperoxidase precursor in said cells.

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