Human myelomonocyte interferon-gamma, and process for preparatio

Details Human myelomonocyte interferon-gamma, and process for preparatio Human myelomonocyte interferon-gamma, and process for preparatio

1993-05-17

1994-11-08

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Lymphokine

Interferon

435 705, 530351, 530413, 424 851, 424 852, 424 856, 424 857, A61K 3766, C12P 2102, C07K 700

Patent

active

053624904

ABSTRACT:
The present invention relates to a novel human interferon-gamma derived from an established human myelomonocyte, a process to prepare said interferon-gamma, and its use. The human myelomonocyte interferon-gamma has a novel polypeptide and carbohydrate chain structure, and it is effective in preventing and treating viral diseases, malignant tumors and immunopathies alone or in combination with other lymphokine and/or chemotherapeutic.

REFERENCES:
patent: 4791101 (1988-12-01), Adolf
patent: 4946674 (1990-08-01), von Eichborn et al.
Yamamoto et al., Studies on the Sugar Chains of Interferon from Human Peripheral-Blood Lymphocytes, J. Biochem. 105:1034-1039 (1989).
Miyata et al. (1986) J. Biochem. 99 1681-1688.
Braude (1984) Biochemistry 23 5603-5609.
Gray et al. (1982) Nature 295:503-508.
Devos et al (1984) J. Interferon Res. 4 461-468.

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