Human MutY

Details Human MutY Human MutY

2011-04-19

2011-04-19

Yu, Misook (Department: 1642)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C536S024310

Reexamination Certificate

active

07927803

ABSTRACT:
A human mutY polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating diseases associated with a mutation in this gene. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.

REFERENCES:
patent: 6013473 (2000-01-01), Wei
patent: 6051222 (2000-04-01), Wei
Bowie et al, Science, 1990, 257:1306-1310).
Burgess et al, J of Cell Bio. 1990, 111:2129-2138.
Lazar et al, Molecular and Cellular Biology, 1988, 8:1247-1252.
Au et al., “Escherichia coli mutYgene product is required for specific A-G → C-G mismatch correction,”PNAS USA, 85:9163-9166 (1988).
Au et al., “Escherichia coli mutYgene encodes an adenine glycosylase active on G-A mispairs,”PNAS USA, 86:8877-8881 (1989).
Bessho et al., “Evidence for Two DNA Repair Enzymes for 8-Hydroxyguanine (7,8-Dihydro-8-oxoguanine) in Human Cells,”J. Biol. Chem., 268(26):19416-19421 (1993).
Cabrera et al., “mutM, a Second Mutator Locus inEscherichia colithat Generates G-C → T-A Transversions,”J. Bacteriol., 170(11):5405-5407 (1988).
Claverys et al., “Heteroduplex Deoxyribonucleic Acid Base Mismatch Repair in Bacteria,”Microbiol. Rev., 50(2):133-165 (1986).
Jones et al., “Repair of a Mismatch Is Influenced by the Base Composition of the Surrounding Nucleotide Sequence,”Genetics, 115:605-610 (1987).
Lieb, M., “Specific Mismatch Correction in Bacteriophage Lambda Crosses by Very Short Patch Repair,”Mol. Gen. Genet., 191:118-125 (1983).
Lieb et al., “Very Short Patch Mismatch Repair In Phage Lambda: Repair Sites And Length Of Repair Tracts,”Genetics, 114:1041-1060 (1986).
Lu et al., “Repair of Single Base-Pair Transversion Mismatches ofEscherichia coliin Vitro: Correction of Certain A/G Mismatches Is Independent ofdamMethylation and HostmutHLSGene Functions,”Genetics, 118:593-600 (1988).
Maki et al., “MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis,”Nature, 355:273-275 (1992).
McGoldrick et al., “Characterization of a Mammalian Homolog of theEscherichia coli MutYMismatch Repair Protein,”Mol. Cell. Biol., 15(2):989-996 (Feb. 1995).
Michaels et al., “MutY, an adenine glycosylase active on G-A mispairs, has homology to endonuclease III,”Nucl. Acids Res., 18(13):3841-3845 (1990).
Michaels et al., “Evidence that MutY and MutM combine to prevent mutations by an oxidatively damaged form of guanine in DNA,”PNAS USA, 89:7022-7025 (1992).
Michaels et al., “The GO System Protects Organisms from the Mutagenic Effect of the Spontaneous Lesion 8-Hydroxyguanine (7,8-Dihydro-8-Oxoguanine),”J. Bacteriol., 174(20):6321-6325 (1992).
Michaels et al., “A Repair System for 8-Oxo-7,8-dihydrodeoxyguanine,”Biochem., 31:10964-10968 (1992).
Modrich, P., “Mechanism And Biological Effects of Mismatch Repair,”Annu. Rev. Genet., 25:229-253 (1991).
Radany, E.H., “Expression Cloning Of A Candidate Human MutY Homolog,”J. Cell. Biochem., Supp. 21A:298, Abstract No. C5-240 (Mar./Apr. 1995).
Radicella et al., “Some mismatch repair activities inEscherichia coli,” PNAS USA, 85:9674-9678 (1988).
Radicella et al., “Patch Length of Localized Repair Events: Role of DNA Polymerase I inmutY-Dependent Mismatch Repair,”J. Bacteriol., 175(23):7732-7736 (1993).
Radman et al., “Mismatch Repair inEscherichia coli,” Ann. Rev. Genet., 20:523-538 (1986).
Raposa et al., “Some Features of Base Pair Mismatch and Heterology Repair inEscherichia coli,” Genetics, 117:381-390 (1987).
Sakumi et al., “Cloning and Expression of cDNA for a Human Enzyme that Hydrolyzes 8-Oxo-dGTP, a Mutagenic Substrate for DNA Synthesis,”J. Biol. Chem., 268(31):23524-23530 (1993).
Slupska et al., “Cloning and sequencing a human homolog (hMYH) of theEscherichia colimutY gene whose function is required for the repair of oxidative DNA damage”,J. Bacteriol., 178(13):3885-3892 (Jul. 1996).
Su et al., “Mispair Specificity of Methyl-directed DNA Mismatch Correction in Vitro,”J. Biol. Chem., 263(14):6829-6835 (1988).
Tsai-Wu et al., “Nucleotide Sequence of theEscherichia coli micAGene Required for A/G-Specific Mismatch Repair: Identity of MicA and MutY,”J. Bacteriol., 173(6):1902-1910 (1991).
Tsai-Wu et al., “Escherichia coliMutY protein has both N-glycosylase and apurinic/apyrimidinic endonuclease activities on A-C and A-G mispairs,”PNAS USA, 89:8779-8783 (1992).
Tsai-Wu et al., “Escherichia coli mutY-dependent mismatch repair involves DNA polymerase I and a short repair tract,”Mol. Gen. Genet., 244:444-450 (1994).
Xu et al., “Determining the Site and Nature of DNA Mutations with the Cloned MutY Mismatch Repair Enzyme,”Carcinogenesis, 17(2):321-326 (Feb. 1996).
Young et al., “Efficient isolation of genes by using antibody probes,”PNAS USA, 80:1194-1198 (1983).
GenBank Accession No. T09329, submitted by M. Adams, et al. (Aug. 1993).
GenBank Accession No. T33107, submitted by M. Adams, et al. (Sep. 1995).
GenBank Accession No. W14150, submitted by M. Marra, et al. (Sep. 1996).
GenBank Accession No. AA306293, submitted by M. Adams, et al. (Apr. 1997).
GenBank Accession No. AA409965, submitted by M. Ko, et al. (May 1997).
GenBank Accession No. AA461247, submitted by L. Hillier, et al. (Jun. 1997).
GenBank Accession No. AA510123, submitted by M. Marra, et al. (Jul. 1997).
GenBank Accession No. W14774, submitted by M. Marra, et al. (Sep. 1996).
GenBank Accession No. AA325423, submitted by M. Adams, et al. (Apr. 1997).
GenBank Accession No. R08531, submitted by L. Hillier, et al. (Apr. 1995).
GenBank Accession No. AA848080, submitted by Cancer Genome Anatomy Project (Apr. 1998).
GenBank Accession No. AA861673, submitted by Cancer Genome Anatomy Project (Mar. 1998).
GenBank Accession No. N24004, submitted by L. Hillier, et al. (Dec. 1995).
GenBank Accession No. AA815101, submitted by Cancer Genome Anatomy Project (Mar. 1998).
GenBank Accession No. AA813309, submitted by Cancer Genome Anatomy Project (Feb. 1998).
GenBank Accession No. AA767487, submitted by Cancer Genome Anatomy Project (Feb. 1998).
GenBank Accession No. AA349792, submitted by M. Adams, et al. (Apr. 1997).
GenBank Accession No. AA765650, submitted by Cancer Genome Anatomy Project (Feb. 1998).
GenBank Accession No. R49993, submitted by L. Hillier, et al. (May 1995).
GenBank Accession No. AA409964, submitted by M. Ko, et al. (May 1997).
GenBank Accession No. W57585, submitted by L. Hillier, et al. (Oct. 1996).
GenBank Accession No. AA847446, submitted by Cancer Genome Anatomy Project (Mar. 1998).
GenBank Accession No. AA516416, submitted by Cancer Genome Anatomy Project (Aug. 1997).
GenBank Accession No. AA534096, submitted by Cancer Genome Anatomy Project (Aug. 1997).
GenBank Accession No. H07650, submitted by Sohn, U., et al. (Jun. 1995).

Affiliated with

Also associated with

Rating

Human MutY does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Human MutY, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human MutY will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2636801