Human MutY

Details Human MutY Human MutY

1999-03-29

2000-04-18

Carlson, Karen Cochrane

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

435200, 435 691, A61K 3846, C12N 924, C12P 2106

Patent

active

060512229

ABSTRACT:
A human mutY polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating diseases associated with a mutation in this gene. Diagnostic assays for identifying mutation in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.

REFERENCES:
Au, K. G. et al., "Escherichia coli mutY gene product is required for specific A-G.fwdarw.C-G mismatch correction," Proc. Natl. Acad. Sci. USA 85:9163-9166 (1988).
Au, K. G. et al., "Escherichia coli mutY gene encodes an adenine glycosylase active on G-A mispairs," Proc. Natl. Acad. Sci. USA 86:8877-8881 (1989).
Bessho, T. et al., "Evidence for Two DNA Repair Enzymes for 8-Hydroxyguanine (7,8-Dihydro-8-oxoguanine) in Human Cells," J. Biol. Chem. 268:19416-19421 (1993).
Cabrera, M. et al., "mutM, a Second Mutator Locus in Escherichia coli That Generates G-C.fwdarw.T-A Transversions," J. Bacteriol. 170:5405-5407 (1988).
Claverys, J. -P. and Lacks, S. A., "Heteroduplex Deoxyribonucleic Acid Base Mismatch Repair in Bacteria," Microbiol. Rev. 50:133-165 (1986).
Jones, M. et al., "Repair of a Mismatch Is Influenced by the Base Composition of the Surrounding Nucleotide Sequence," Genetics 115:605-610 (1987).
Lieb, M., "Specific Mismatch Correction in Bateriophage Lambda Crosses by Very Short Patch Repair," Mol. Gen. Genet. 191:118-125 (1983).
Lieb, M., et al., "Very Short Patch Mismatch Repair in Phage Lambda: Repair Sites and Length of Repair Tracts," Genetics 114:1041-1060 (1986).
Lu, A-L. and Chang, D.-Y., "Repair of Single Base-Pair Transversion Mismatches of Escherichia coli In Vitro: Correction of Certain A/G Mismatches is Independent of dam Methylation and Host mutHLS Gene Functions," Genetics 118:593-600 (1988).
Maki, H. and Sekiguchi, M., "MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis," Nature 355:273-275 (1992).
McGoldrick, J. P. et al., "Characterization of a Mammalian Homolog of the Eschericia coli MutY Mismatch Repair Protein," Mol. Cell. Biol. 15:989-996 (1995).
Michaels, M. L. et al., "MutY, an adenine glycosylase active on G-A mispairs, has homology to endonuclease III," Nucl. Acids Res. 18:3841-3845 (1990).
Michaels, M. L. et al., "Evidence that MutY, and MutM combine to prevent mutations by an oxidatively damaged form of guanine in DNA," Proc. Natl. Acad. Sci. USA 89:7022-7025 (1992).
Michaels, M. L. and Miller, J. H., "The Go System Protects Organisms from the Mutagenic Effect of the Spontaneous Lesion 8-Hydroxyguanine (7,8-Dihydro-8-Oxoguanine)," J. Bacteriol. (20):6321-6325 (1992).
Michaels, M. L. et al., "A Repair System for 8-Oxo-7,8-dihydrodeoxyguanine," Biochemistry 31:10964-10968 (1992).
Modrich, P., "Mechanisms and Biological Effects of Mismatch Repair," Annu. Rev. Genet. 25:229-253 (1991).
Radany, E. H. "Expression Cloning of a Candidate Human MutY Homolog." J. Cell. Biochem. Supp. 21A:298, Abstract No. C5-240 (Mar./Apr. 1995).
Radicella, J. P. et al., "Some mismatch repair activities in Escherichia coli," Proc. Natl. Acad. Sci. USA 85:9674-9678 (1988).
Radicella, J. P. et al., "Patch Length of Localized Repair Events: Role of DNA Polymerase I in mutY-Dependent Mismatch Repair," J. Bacteriol. 175:7732-7736 (1993).
Radman, M. and Wagner, R., "Mismatch Repair in Eschericia Coli," Ann. Rev. Genet. 20:523-538 (1986).
Raposa, S. and Fox, M. S., "Some Features of Base Pair Mismatch and Heterology Repair in Escherichia Coli," Genetics 117:381-390 (1987).
Sakumi et al., "Cloning and Expression of cDNA for a Human Enzyme that Hydrolyzes 8-oxo-dGTP, a Mutagenic Substrate for DNA Synthesis" J. Biol. Chem. 268:23524-23530 (1993).
Su, S. -S. et al., "Mispair Specificity of Methyl-directed DNA Mismatch Correction in Vitro," J. Biol. Chem. 263(14):6829-6835 (1988).
Tsai-Wu, J. -J. et al., "Nucleotide Sequence of the Escherichia coli. micA Gene Required for A/G-Specific Mismatch Repair: Identity of MicA and MutY," J. Bacteriol. 173:1902-1910 (1991).
Tsai-Wu, J. -J. et al., "Escherichia coli MutY protein has both N-glycosylase and apurinic/apyrimidinic endonuclease activities on A-C and A-G mispairs," Proc. Natl. Acad. Sci. USA 89:8779-8783 (1992).
Tsai-Wu, J.-J. and Lu, A.-L., "Escherichia coli mutY-dependent mismatch repair involves DNA polymerase I and a short repair tract," Mol. Gen. Genet. 244(4):444-450 (1994).
Xu, J.F. et al., "Determining the Site and Nature of DNA Mutations With the Cloned MutY Mismatch Repair Enzyme," Carcinogenesis 17:321-326 (1996).
Young, R.A. et al., "Efficient Isolation of Genes by Using Antibody Probes," Proc. Natl. Acad. Sci. U.S.A. 80:1194-1198 (1983).
International Search Report for International Application No. PCT/US96/03239 (Mailing Date: Jul. 19, 1996).
GenBank Report, Accession No. T09329, submitted by M. Adams, et al. (Aug. 1993).
GenBank Report, Accession No. T33107, submitted by M. Adams, et al. (Sep. 1995).
GenBank Report, Accession No. W14150, submitted by M. Marra, et al. (Sep. 1996).
GenBank Report, Accession No. AA306293, submitted by M. Adams, et al. (Apr. 1997).
GenBank Report, Accession No. AA409965, submitted by M. Ko, et al. (May 1997).
GenBank Report, Accession No. AA461247, submitted by L. Hillier, et al. (Jun. 1997).
GenBank Report, Accession No. AA510123, submitted by M. Marra, et al. (Jul. 1997).
GenBank Report, Accession No. W14774, submitted by M. Marra, et al. (Sep. 1996).
GenBank Report, Accession No. AA325423, submitted by M. Adams, et al. (Apr. 1997).
GenBank Report, Accession No. R08531, submitted by L. Hillier, et al. (Apr. 1995).
GenBank Report, Accession No. AA848080, submitted by Cancer Genome Anatomy Project (Apr. 1998).
GenBank Report, Accession No. AA861673, submitted by Cancer Genome Anatomy Project (Mar. 1998).
GenBank Report, Accession No. N24004, submitted by L. Hillier, et al. (Dec. 1995).
GenBank Report, Accession No. AA815101, submitted by Cancer Genome Anatomy Project (Mar. 1998).
GenBank Report, Accession No. AA813309, submitted by Cancer Genome Anatomy Project (Feb. 1998).
GenBank Report, Accession No. AA767487, submitted by Cancer Genome Anatomy Project (Feb. 1998).
GenBank Report, Accession No. AA349792, submitted by M. Adams, et al. (Apr. 1997).
GenBank Report, Accession No. AA765650, submitted by Cancer Genome Anatomy Project. (Feb. 1998).
GenBank Report, Accession No. R49993, submitted by L. Hillier, et al. (May 1995).
GenBank Report, Accession No. AA409964, submitted by M. Ko, et al. (May 1997).
GenBank Report, Accession No. W57585, submitted by L. Hillier, et al. (Oct 1996).
GenBank Report, Accession No. AA847446, submitted by Cancer Genome Anatomy Project (Mar. 1998).
GenBank Report, Accession No. AA516416, submitted by Cancer Genome Anatomy Project (Aug. 1997).
GenBank Report, Accession No. AA534096, submitted by Cancer Genome Anatomy Project (Aug. 1997).
GenBank Report, Accession No. H07650, submitted by Sohn, U. et al. (Jun. 1995).

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