Human mutT2

Details Human mutT2 Human mutT2

1997-08-21

2000-08-15

Riley, Jezia

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530300, 5303881, 5303882, 536 231, 435 6, A61K 3800, C07K 100, C07H 2102, C12Q 168

Patent

active

061038717

ABSTRACT:
A human hMutT2 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for hydrolyzing and eliminating oxidized guanine nucleotides from the nucleotide pool to ensure correct DNA synthesis. Diagnostic assays are also disclosed which detect the presence of a mutated form of hMutT2 and over-expression of the hMutT2 protein.

REFERENCES:
patent: 5227471 (1993-07-01), Wright, Jr.
International Search Report, Application No. PCT/US94/13187.
Sakumi et al. (1993) J. Bio. Chem. 268(31):23524-23530.
Mo et al. (1992) PNAS 89:11021-11025.
Tchou et al. (1993) Mut. Res. 299:277-287.
Akiyama et al. (1987) Mol. & Gen. Genetics 296:9-16.
Lathe, R. (1985) J. Mol. Biol. 183:1-12.
Tijan et al. (1994) Cell 77:5-8.
Ranish et al. (1992) Science 255:1127-1129.
Makai et al. (1992) Nature 355:273-275.
Cross et al. (1994) Nature Genetics 6:236-244.
New England Biolabs Catalog, Beverly, MA, USA, p. 60 (1986).
Devlin "Textbook of Biochemistry with Clinical Correlations", published by A. Wiley, pp. 986-987 (1982).
Accession No. HS41H10F (Oct. 23, 1995).

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