Human mutant tissue factor compositions useful as tissue factor

Details Human mutant tissue factor compositions useful as tissue factor Human mutant tissue factor compositions useful as tissue factor

1998-03-05

1999-11-30

Carlson, Karen Cochrane

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 530350, 530381, 435 71, A61K 3816, C07K 14745, G01N 3353

Patent

active

059942967

ABSTRACT:
The present invention describes a mutant human tissue factor protein which binds functional Factor VII/VIIa but is substantially free of functional procoagulant cofactor activity, and compositions containing the mutant protein. Also disclosed are methods for using the mutant human tissue factor proteins, and recombinant DNA vectors for expressing the protein.

REFERENCES:
Roy, S, Hass, PE, Bourell, JH, Henzel, WJ, Vehar, GA, "Lysine Residues 165 and 166 are Essential for the Cofactor Function of Tissue Factor", J. Biol. Chem. 266(32): 22063-22066, Nov. 15, 1991.

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