Human-murine chimeric antibodies against respiratory syncytial v

Details Human-murine chimeric antibodies against respiratory syncytial v Human-murine chimeric antibodies against respiratory syncytial v

1994-08-15

1998-10-20

Caputa, Anthony C.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Structurally-modified antibody, immunoglobulin, or fragment...

4241421, 4241471, 4241591, 5303873, 53038815, 5303883, A61K 3942, C07K 1608

Patent

active

058243070

ABSTRACT:
This invention relates to a human antibody which contains the one CDR from each variable heavy and variable light chain of at least one murine monoclonal antibody, against respiratory syncytial virus which is MAb1129 and the use thereof for the prevention and/or treatment of RSV infection.

REFERENCES:
patent: 4659563 (1987-04-01), Dobkin
patent: 4717766 (1988-01-01), Dobkin
patent: 4800078 (1989-01-01), Prince et al.
Tempest et al (1991, Mar.) Biotechnology 9:266-271.
Beeler et al (1989) J. Virol. 63(7):2941-2950.
Jones et al (1986) Nature 329:522-525.
Roitt (1991) "Essential Immunology", Blackwell Scientific Publications, Oxford, pp. 65-68 & 74.

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