Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Oxidoreductases
Patent
1998-03-17
1999-06-29
Prouty, Rebecca E.
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Oxidoreductases
435191, 435199, A61K 3844, C12N 906, C12N 922
Patent
active
059165561
ABSTRACT:
The present invention provides a polynucleotide which identifies and encodes a novel human mRNA editing enzyme (REE). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding REE. The invention also provides for the use of substantially purified REE and its agonists, antagonists, or inhibitors in the commercial production of recombinant proteins and in pharmaceutical compositions for the treatment of diseases associated with the expression of REE. Additionally, the invention provides for the use of antisense molecules to REE in pharmaceutical compositions for treatment of diseases associated with the expression of REE. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of polynucleotides encoding REE or anti-REE antibodies which specifically bind to REE.
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Au-Young Janice
Hawkins Phillip R.
Hillman Jennifer L.
Incyte Pharmaceuticals Inc.
Prouty Rebecca E.
Stole Einar
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