Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Primate cell – per se
Patent
1997-02-28
1998-09-08
Weber, Jon P.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Primate cell, per se
435372, C12N 500
Patent
active
058044434
ABSTRACT:
The present invention comprises a novel immortal human monocytic leukemia cell line, designated MC-1010. This cell line has been demonstrated to induce an immune response when injected into non-human primates. This leukemic cell line is also a source of a unique ATPase that is found in only low levels in normal human cells. The immortal nature of the MC-1010 cell line allows it to be used as the replicative fusion partner for making hybridomas and also makes it an excellent source of enzymes (e.g., telomerase) and other cellular components involved in the cellular replication process.
REFERENCES:
patent: 5272082 (1993-12-01), Santoli et al.
Atkinson, Cellular Energy Metabolism and Its Regulation, Academic Press, New York, 1977.
Bernofsky et al., "Latency of Adenosine 5'-Triphosphate in MC-1010 Cells," Biochemical Archives 9:51-64 (1993).
Bernofsky et al., "Spin trapping endogenous radicals in MC-1010 cells: Evidence for hydroxyl radical and carbon-centered ascorbyl radical adducts," Molecular and Cellular Biochemistry 148:155-164 (1995).
Counter et al., "Telomerase activity in human ovarian carcinoma," Proc. Natl. Acad. Sci. 91:2900 (1994).
Harlow and Lane, Antibodies: A Laboratory Manual (Cold Spring Harbor, Cold Spring Harbor, N.Y., 1988).
Holmsen and Dangelmaier, "Measurement of Secretion of Adenine Nucleotides," Meth. Enzymol. 169:195 (1989).
Lange et al., "Growth Factor Requirements of Childhood Acute Leukemia: Establishment of GM-CSF-Dependent Cell Lines," Blood 70(1):192-199 (1987).
Lundin, "Analytical Applications of Bioluminescence: The Firefly System," Clinical and Biochemical Luminescence (Kricka and Carter, ed.), Marcel Dekker, New York, 1982, p. 43.
O'Connor et al., "Growth Factor-Dependent Differentiation Along the Myeloid and Lymphoid Lineages in an Immature Acute T Lymphocytic Leukemia," J. Immunol. 145:3779 (1990).
Santoli et al., "Synergistic and Antagonistic Effects of Recombinant Human Interleukin (IL) 3, IL-1.alpha., Granulocyte and Macrophage Colony-Stimulating Factors (G-CSF and M-CSF) on the Growth of GM-CSF-Dependent Leukemic Cell Lines," The Journal of Immunology 139(10):3348-3354 (1987).
Santoli et al., "Synergistic and Antagonistic Effects of IL-1.alpha. and IL-4, Respectively, on the IL2-Dependent Growth of a T Cell Receptor-.gamma..delta..sup.+ Human T Leukemia Cell Line," J. Immunol. 144:4703 (1990).
Stanley, "Extraction of Adenosine Triphosphate from Microbial and Somatic Cells," Meth. Enzymol. 133:14 (1986).
Tang et al., "Isolation of a Novel Atpase From Leukemic Monocytes," FASEB J. 7:A717 (1993).
Wulff and Doppen, "Luminometric Method," in Methods of Enzymatic Analysis, 3 ed., vol. 7 (Bergmeyer, Bergmeyer, and Gra.beta.l, ed.) VCH Pub., Weinheim, 1985, p. 357.
Chang et al. (1975) Biochem. Biophys. Res. Comm., 64(2), "Correlation Between DNA Synthesis and Intracellular NAD in Cultured Human Leukemic Lymphocytes", pp. 539-545.
Sombrook et al. (1989) Molecular Cloning A Laboratory Manual, 2md Edn., Cold Spring Harbor Laboratory Press, pp. xxxii-xxxv.
LandOfFree
Human monocytic leukemia cell line does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Human monocytic leukemia cell line, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human monocytic leukemia cell line will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1281344