Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Hormones – e.g. – prolactin – thymosin – growth factors – etc.
Patent
1990-10-31
1993-06-01
Moezie, F. T.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Hormones, e.g., prolactin, thymosin, growth factors, etc.
530324, 4352402, 43524025, 435 701, 436 63, 436 86, 436 68, 514 2, 514 21, C07K 1500, C07K 1506
Patent
active
052161331
ABSTRACT:
A novel growth factor, human monocyte growth factor, stimulating proliferation and differentiation of human peripheral blood monocyte. The factor is a protein produced from human lung cancer cell line and having M.W. of about 21,000. The activity of the factor is heat-sensitive, trypsin-sensitive, chymotrypsin-sensitive, and destroyed by 2-mercaptoethanol. A purification process of the factor is also provided.
REFERENCES:
patent: 4879111 (1989-11-01), Chong
Journal of Cellular Biochemistry, vol. 40, No. 1, May 1, 1989, New York, pp. 193-199; S. M. Wahl et al.: "Role of Growth Factors in Inflammation and Repair".
Dinarello and Mier, "Lymphokines," New Engl. J. Med., 317 (15):940-945 (1987).
Sieff, "Hematopoietic Growth Factors," J. Clin. Invest., 79:1549-1557 (1987).
Metcalf, "The Molecular Control of Cell Division, Differentiation Commitment and Maturation in Haemopoietic Cells," Nature 339:27-30 (1989).
Ohta et al., "Induction of Proliferation of Human Circulating Monocytes In Vitro by Lectin-Induced Factor(s) from Lymphocytes," Biochem. Biophys. Res. Commun., 126 (2):705-711 (1985).
Okabe et al., "A Human Monocyte Growth Factor Produced by Lung Cancer Cells," Cancer Research, 5:3863-3865 (1990).
Ohta et al., "1.alpha.,25-Dihydroxyvitamin D.sub.3 (Calcitriol) Stimulates Proliferation of Human Circulating Monocytes In Vitro," FEBS Letter, 185 (1):9-13 (1985).
Kirkin Brewery KK, JA0140788, Nov. 1979, abstract in English language.
Clark et al., Science, 236, 1229-1237, 1987.
Japan Antibiotics Research Association
Moezie F. T.
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