Human monocyte elastase inhibitor antibodies

Details Human monocyte elastase inhibitor antibodies Human monocyte elastase inhibitor antibodies

1996-06-13

1998-10-27

Eisenschenk, Frank C.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 71, 5303879, 53033815, 53038826, C07K 1600, C12P 2108, G01N 3353, G01N 33537

Patent

active

058276726

ABSTRACT:
A new human elastase inhibitor is provided. The human monocyte elastase inhibitor is isolated, purified, characterized at the molecular level and cloned. The human monocyte elastase inhibitor is capable of forming a covalent complex with elastase or Proteinase-3 and is capable of inhibiting elastase.

REFERENCES:
patent: 5364619 (1994-11-01), Packard et al.
Baggiolini et al. Agents and Actions, 1978, 8:3-10.
Vaitukaitis, J. Methods in Enzymology, 1981, 73:46-52.
Giri, I., et al.., Proc. Natl. Acad. Sci. USA, 1985, 82:1580-1584.
Sofer, G. and V. Britton, Biotechniques, Nov/Dec 1983, 198-203.
Janoff, A., et al., Proc. Soc. Biol. Med., 1971, 136:1050-1053.
Blondin, J., et al., Am. Rev. Resp. Dis., 1972. 106:477-479.
Dubin, A., Eur, J. Biochem., 1977, 73:429-435.
Remold-O'Donnell, E., et al., J. Biol. Chem., 1983, 258:3251-3257.
Kopitar, M., et al., Acta Pharm., Jugosl., 1985, 35:203-212.
Valentine, R., et al., Proc. Soc. Exp. Biol. Med., 1981, 168:238-244.
Potempa, J., et al., J. Biol. Chem., 1988, 263:7364-7369.
Hintz, P., et al., Biol. Chem. Hoppe-Seyler, 1987, 368:1333-1342 and "Biol. Abstracts", vol. 85, No. 3, 1988, Ref. No. 27273.
Remold-O'Donnell et al. J. Exp. Med., 1989, 169:1071-1986.
Welgus, H., et al., J. Clin. Invest., 1986, 77:1675-1681.
Senoir, R., et al., J. Clin. Invest., 1982, 69:384-393.
Sinha, S., Proc. Natl. Acad. Sci. USA, 1987, 84:2228-2232.
Takahashi, H., et al., J. Biol. Chem., 1988, 263(5):2543-2547.
Suggs, S., et al., Proc. Natl. Acad. Sci. USA, 1981, 78(11);6613-6617.
Garvey et al., Methods in immunology, 3rd Edition, March 1977, pp. 194-231.
Junger, W., Biol. Chemistry Hoppe-Seyler, 369:63-68, supplement (1988).
Thomas, R., et al. FASEB Journal, 4:A2156, Abstract No. 2682 (1990).
Takeuchi, K., et al. J. Biol. Chem., 264:7431-7436 (1989).
Thomas, R., et al., J. Leukocyte Biology, 50:568-579 (1991).
DBA Abstract, Accession No. 88-04290, European Patent No. EP 255011, Feb. 3, 1988.
Biosis Abstract, Accession No. 83054104, Von Wilcken-Bergmann et al, EMBO 55(12):3219-3226 (1986).
Jallat, S. et al., "Altered specificities of genetically engineering alpha 1-antitrypsin variants" Prot. Engr. 1 (1):29-35 (1986).
Patston, P.A. et al., "Reactivity of alpha1-antitrypsin mutants against proteolytic enzymes of the kallikrein-kinin, complement, and fibrinolytic sustems" J. Biol. Chem. 265(18):10786-10791 (1989).
Bishoff, R. et al., "Purification and biochemical characterization of recombinant alpha1-antitrypsin variants expressed in Escherichia coli" Biochem. 30:3464-2472 (1991).
Schulze, A.J. et al., "Inhibitory activity and conformational translation of alpha 1-proteinase inhibitor variants" Eur. J. Biochem. 202:1147-1156 (1991).
Stephens, A.W. et al., "Site-directed mutagenesis of the reactive center (Series 394) of antithrombin III" J. Biol. Chem. 263(31):15849-15852 (1988).
George, P.M. et al., "Charaterization of antithrombins produced by active site mutagenesis of human alpha-1-antitrypsin expressed in yeast" Blood 73(2):490-496 (1989).
Brennan, S.O. et al., "Alpha-1-antitrypsin Christchrich, 369 Glu to Lys: mutation at the P5.sup.1 position does not affect inhibitory activity" Biochim. Biophys. Acta 873:13-19 (1986).
Remold-O'Donnell, E. "The ovalbumin family of serpin proteins" FEBS Lett. 315(2):105-108 (1993).
Stein, P.E. et al., "Crystal structure of ovalbumin as in model for the reactive centre of serpins", Nature 347:99-102 (1990).
Stein, P.E. et al., "Crystal structure of uncleaved ovalbumin at 1.95 .ANG.resolution" J. Mol. Biol. 221: 941-959 (1991).
Takahashi, N. et al., "Role of an intrachain disulfide bond in the conformation and stability of ovalbumin" J. Biochem, 109:846-851 (1991).
Remold-O'Donnell, E., "Sequence and molecular characterization of human monocyte
eutrophil elastase inhibitor" PNAS, USA 89:5635-5639 (1992).
Remold-O'Donnell (1985) A Fast-acTing elastase inhibitor in human monocytes J. Exp. Med. 162(6): 2142-2155.
Johnstone et al. (1988) Immunohistochemistry in practice. Blackwell Scientific Publications, Oxford second editor.

Affiliated with

Also associated with

Rating

Human monocyte elastase inhibitor antibodies does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Human monocyte elastase inhibitor antibodies, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human monocyte elastase inhibitor antibodies will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1612986