Human monocyte elastase inhibitor

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435218, C07K 1447, C12N 966

Patent

active

056632991

ABSTRACT:
A new human elastase inhibitor is provided. The human monocyte elastase inhibitor is isolated, purified, characterized at the molecular level and cloned. The human monocyte elastase inhibitor is capable of forming a covalent complex with elastase or Proteinase-3 and is capable of inhibiting elastase.

REFERENCES:
patent: 5364619 (1994-11-01), Packard et al.
Remold-O'Donnell, E, (1993) "The ovalbumin family of serpin proteins" FEBS Lett. 315(2):105-108.
Stein, P.E. et al. (1990) "Crystal structure of ovalbumin as a model for the reactive centre of serpins" Nature 347:99-102.
Stein, P.E. et al. (1991) "Crystal structure of uncleaved ovalbumin at 1.95 .ANG. resolution" J. Mol. Biol. 221:941-959.
Takahashi, N. et al. (1991) "Role of an intrachain disulfide bond in the conformation and stability of ovalbumin" J. Biochem. 109:846-851.
Vaitukaitis, J., Methods in Enzymology, 1981, 73:46-52.
Giri, I., et al., Proc. Natl. Acad. Sci. USA, 1985, 82:1580-1584.
Sofer, G. and V. Britton, Biotechniques, Nov./Dec. 1983, 198-203.
Remold-O'Donnell, E., J. Exp. Med., 1985, 162:2142-2155.
Janoff, A., et al., Proc. Soc. Biol. Med., 1971, 136:1050-1053.
Blondin, J., et al., Am. Rev. Resp. Dis., 1972, 106:477-479.
Dubin, A., Eur. J. Biochem., 1977, 73:429-435.
Remold-O'Donnell, E., et al., J. Biol. Chem., 1983, 258:3251-3257.
Kopitar, M., et al., Acta Pharm. Jugosl., 1985, 35:203-212.
valentine, R., et al., Proc. Soc. Exp. Biol. Med., 1981, 168:238-244.
Potempa, J., et al., J. Biol. Chem., 1988, 263:7364-7369.
Hintz, P., et al., Biol. Chem. Hoppe-Seyler, 1987, 368:1333-1342 and "Biol. Abstracts", vol. 85, No. 3, 1988, Ref. No. 27273.
Remold-O'Donnell, et al. J. Exp. Med., 1989, 169:1071-1986.
Welgus, H., et al., J. Clin. Invest., 1986, 77:1675-1681.
Senior, R., et al., J. Clin. Invest., 1982, 69:384-393.
Sinha, S., Proc. Natl. Acad. Sci. USA, 1987, 84:2228-2232.
Takahashi, H., et al., J. Biol. Chem., 1988, 263(5):2543-2547.
Suggs, S., et al., Proc. Natl. Sci. Acad. USA, 1981, 78(11):6613-6617.
Garvey et al., Methods in Immunology, 3rd Edition, Mar. 1977, pp. 194-231.
Junger, W., et al., Biol. Chemistry Hoppe-Seyler, 369:63-68, supplement (1988).
Thomas, R., et al., FASEB Journal, 4:A2156, Abstract No. 2682 (1990).
Takeuchi, K., et al. J. Biol. Chem., 264:7431-7436 (1989).
Thomas, R., et al., J. Leukocyte Biology, 50:568-579 (1991).
DBA Abstract, Accession No. 88-04290, European Patent No. EP 255011, Feb. 3, 1988.
Biosis Abstract, Accession No. 83054104, Von Wilcken-Bergmann et al, EMBO 55 (12), 1986, 3219-3226.
Jallat, S. et al. (1986) "Altered specificities of genetically engineered .alpha..sub.1 -antitrypsin variants" Prot. Engr. 1(1):29-35 1986.
Patston, P.A. et al. (1989) "Reactivity of .alpha..sub.1 -antitrypsin mutants against proteolytic enzymes of the kallilrein-kinin, complement, and fibrinolytic systems" J. Biol. Chem. 265(18):10786-10791 Jun. 1990.
Bischoff, R. et al. (1991) "Purification and biochemical characterization of recombinant .alpha..sub.1 -antitrypsin variants expressed in Escherichia coli" Biochem. 30:3464-3472 1991.
Schulze, A.J. et al. (1991) "Inhibitory activity and conformational transition of .alpha..sub.1 -proteinase inhibitor variants" Eur. J. Biochem. 202:1147-1155 1991.
Stephens, A.W. et al. (1988) "Site-directed mutagenesis of the reactive center (Serine 394) of antithrombin III" J. Biol. Chem. 263(31):15849-15852 Nov. 1988.
George, P.M. et al. (1989) "Characterization of antithrombins produced by active site mutagenesis of human .alpha..sub.-1 -antitrypsin expressed in yeast" Blood 73(2):490-496 Feb. 1989.
Brennan, S.O. et al. (1986) ".alpha..sub.-1 -antitrypsin Christchurch, 363 Glu to Lys: mutation at the P5' position does not affect inhibitory activity" Biochim. Biophys. Acta 873:13-19 Sep. 1986.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Human monocyte elastase inhibitor does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Human monocyte elastase inhibitor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human monocyte elastase inhibitor will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-309377

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.