Human monoclonal antibody to lymphadenopathy-associated virus

Details Human monoclonal antibody to lymphadenopathy-associated virus Human monoclonal antibody to lymphadenopathy-associated virus

1990-03-19

1992-02-11

Nucker, Christine

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435 72, 435 7021, 43524027, 435974, 436811, 436548, 530387, G01N 33569

Patent

active

050875574

ABSTRACT:
Human monoclonal antibodies capable of specifically reacting with an antigenic determinant of LAV/HTLV-III and cell lines producing those monoclonal antibodies are disclosed. The human monoclonal antibodies may be utilized in a method for determining the presence of LAV/HTLV-III in biological samples, or in a method for separating specific antigenic determinants of LAV/HTLV-III from a mixture. Pharmaceutical compositions containing such a human monoclonal antibody, and a method for significantly reducing the infectivity of LAV/HTLV-III in animals using the composition are also disclosed.

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Kipps et al., In Applications of Immunologized Methods in Biomedical Sciences, vol. 4, Edited by D. M. Weis, Black Well Scientific Publishers, 1986.

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