Human monoclonal antibody to antigen of gastric cancer and B-cel

Details Human monoclonal antibody to antigen of gastric cancer and B-cel Human monoclonal antibody to antigen of gastric cancer and B-cel

1986-09-29

1991-06-18

Kepplinger, Esther L.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

4352402, 4351722, 435 7021, 435948, 530388, 935 90, 935 93, 935100, 935104, 935107, 935108, 424 858, 436548, C12N 524, C07K 1528

Patent

active

050249460

ABSTRACT:
The present invention relates to a human B-cell line capable of producing a human monoclonal antibody against an antigen found on gastric cancer cell lines or tissues. The B-cell line is formed by culturing B-cells of a lymph node obtained from a patient with gastric cancer and a HAT sensitive B-cell line. The antigen is also disclosed.

REFERENCES:
patent: 4464465 (1984-08-01), Lostrom
Ochiai et al., "Production and Analysis of Monoclonal Antibody Against Human Gastric Cancer Cell Line", Proceedings of the Japanese Cancer Association, The 44th Annual Meeting, Oct. 1985 (Tokyo), p. 132, Presentation No. 419.
Debus, E. et al., "Monoclonal Cytokeratin Antibodies That Distinguish Simple from Stratified Squamous Epithelia: Characterization on Human Tissues", EMBO J. 1(12): 1641-1647, 1982.
Abe, T. et al., "Human Monoclonal Antibodies Against Cytokeratin 18 Generated from Patients with Gastric Cancer", Jpn. J. Cancer Res., 80:271-276, Mar. 1989.
Moll, R. et al., "The Catalog of Human Cytokeratins: Patterns of Expression in Normal Epithelia, Tumors and Cultured Cells," Cell 31:11-24, Nov. 1982.
Kotaro Koyama et al., Jpn. J. Cancer Res., 81, 967-970, Oct. '90, "Alloimmunization with Cultured Human Stomach Cancer Cell Lines and the Establishments of Human--Human Hybridomas Producing Monoclonal Antibodies".
Ochiai et al., "Proceedings of the Japanese Cancer Assoc.", The 44th Annual Meeting, Oct. 1985, pp. 132, Presentation No. 419.

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