Human monoclonal antibody specifically binding to surface antige

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

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5303871, 5303877, 53038815, 5303897, 530866, C07K 1630, C07K 1618, C07K 1628

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059902876

ABSTRACT:
A human monoclonal antibody specifically binding to a surface antigen of cancer cell membrane, an isolated DNA encoding the antibody, and a hybridoma producing the antibody. An anti-cancer formulation comprising the monoclonal antibody bonded to the surface of a liposome enclosing an anti-cancer agent or toxin is also provided.

REFERENCES:
patent: 4800155 (1989-01-01), Taniguchi et al.
patent: 5264221 (1993-11-01), Tagawa et al.
Cancer Research vol. 45, 263-271, Jan. 1985, Imam et al., Generation and Immunohistological Characterization of Human Monoclonal Antibodies to Mammary Carcinoma Cells.
Cancer Immunol/Immunotherapy (1989) 28: 296-300, Formenti et al., "Reactivity of a Human Monoclonal Antibody Against Carcinomas and other Lesions of the Colon".
Cancer Research vol. 49, 2471-2476, May 1, 1989, Vollmers et al., "SC-1 a Functional Human Monoclonal Antibody Against Autologous Stomach Carcinoma Cells".
Cell vol. 22, 197-207, Nov. 1980, Hieter et al. "Cloned Human and Mouse Kappa Immunoglobulin Constant and J Region Genes Conserve Homology in Functional Segments".
Nature vol. 294, 536-540, Hieter et al., "Clustered Arrangement of Immunoglobulin Constant Region Genes in Man" Dec. 10, 1981.
The Journal of Biological Chemistry vol. 257, 1516-1522, Feb. 1992, Hieter et al., "Evolution of Human Immunoglobulin k J Region Genes".
Nucleic Acids Research, vol. 14, 1779-1789, Huck et al., Sequence of a human immunoglobulin Gamma 3 heavy chain constant region gene: comparison with the other human C genes (1986).
Nucleic Acids Research, vol. 18, 4278, May 1990, Friedlander et al., Complete nucleotide sequence of the membrane form of the human IgM heavy chain.
Nature vol. 321, 522-525, May 1986, Jones et al., "Replacing the complementarity determining regions in a human antibody with those from a mouse".
Chen et al., J. Cancer Res. Clin. Oncol., 117 (4), pp. 367-376, 1991.
Liu et al., Chung Hug Chung Liv Tsu Chih, 10(4), pp. 242-244, 1988.
Harris et al., TIBTECH, 11, pp. 42-44, 1993.
Dermer, Bio/Technology, 12, p. 320, 1994.
Hird et al., Chapter 12, from: Genes and Cancer, Ed.
D. Carney, et al., Wiley and Sons, pp. 183-189, 1990.
Saito et al., J. Natl. Cancer Institute 80(10), pp. 728-738, 1988.
Waldman, Science, vol. 262, pp. 1657-1662, 1991.
Parks et al., Chapter 29, From Handbook of Exp. Immunol. vol. 1, Immunochemistry, Blackwell Scientific Pub, 1986.
Chemical Abstracts, vol. 111, No. 13, Sep. 25, 1989 Kazuhiro Yoshikawa et al. "A Human Monoclonal Antibody Recognizing a Surface Antigen on Stomach Cancer Cells.", p. 503, Col. 2, Abstract-No. 113 362y.
Chemical Abstracts, vol. 100, No. 21, May 21, 1984 Takashi Masuko et al. "Monoclonal Antibodies Against Cell Surface Antigens Present on Human Urinary Bladder Cancer Cells.", p. 474, Col. 1, Abstract-No. 172 850b.

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