Human monoclonal antibody specific lipopolysaccharides (LPS)...

Details Human monoclonal antibody specific lipopolysaccharides (LPS)... Human monoclonal antibody specific lipopolysaccharides (LPS)...

2005-11-10

2009-10-06

Swartz, Rodney P. (Department: 1645)

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

C424S130100, C424S133100, C424S137100, C424S141100, C424S142100, C424S164100, C424S170100, C424S178100, C530S809000

Reexamination Certificate

active

07597893

ABSTRACT:
The present application relates to a human monoclonal antibody specific for the serotype IATS 06 ofP. aeruginosa, a hybridoma producing it, nucleic acids encoding it, and host cells transfected therewith. Further, the present invention relates to methods for producing said monoclonal antibody. In addition, the present invention relates to pharmaceutical compositions comprising at least one antibody or at least one nucleic acid encoding said antibody.

REFERENCES:
patent: 4834975 (1989-05-01), Siadak et al.
patent: 0 441 395 (1991-08-01), None
patent: 02/20619 (2002-03-01), None
Cryz, S.J. et al., “Safety and Immunogenicity of aPseudomonas aeruginosaO-Polysaccharide Toxin A Conjugate Vaccine in Humans,”Journal of Clinical Investigation, vol. 80(1), pp. 51-56, 1987.
Hemachandra, S. et al., “Human Monoclonal Antibodies AgainstPseudomonas aeruginosaLipopolysaccharide Derived from Transgenic Mice Containing Megabase Human Immunoglobulin Loci are Opsonic and Protective Against FatalPseudomonas sepsis,” Infection and Immunity, vol. 69(4), pp. 2223-2229, 2001.
Persic et al., “An Integrated Vector System for the Eukaryotic Expression of Antibodies or Their Fragments After Selection from Phage Display Libraries,”Gene, vol. 187(1), pp. 9-18, 1997.

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