Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Reexamination Certificate
2007-07-10
2007-07-10
Campell, Bruce R. (Department: 1648)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
C424S093100, C530S338000, C530S387100, C530S300000
Reexamination Certificate
active
10343015
ABSTRACT:
Disclosed is a hybridoma cell line which produces human antibodies capable of binding to the hepatitis C virus (HCV) E2 glycoprotein and capable of neutralizing HCV infection in vivo in an animal model, as well as antibodies produced by the cell line. Also disclosed are various uses of said antibodies in the prevention and treatment of HCV infection. Peripheral blood lymphocytes obtained from human donors having a high titer of anti HCV E2 antibodies are transformed in vitro by Epstein-Barr virus and then fused with heteromyeloma cells to generate hybridomas secreting human antibodies having a high affinity and specificity to HCV E2 glycoprotein.
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Da Silva Cardoso Marcia
Dagan Shlomo
Eren Rachel
Kubanek Bernhard
Sifmoneit Karl
Browdy and Neimark PLLC
Campell Bruce R.
DRK-Blutspendedienst Baden-Wurttemberg
Li Bao Qun
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