Human monoclonal antibodies to the islet cell antigen IA-2

Chemistry: analytical and immunological testing – Involving production or treatment of antibody

Reexamination Certificate

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C436S548000, C530S380000, C530S388100, C530S388150, C530S861000, C530S866000, C530S868000

Reexamination Certificate

active

06967108

ABSTRACT:
The invention concerns human monoclonal antibodies to the islet cell antigen IA-2, a process for their production, the use of human monoclonal antibodies in a method for detecting antibodies to IA-2, a method for detecting antibodies to the islet cell antigen IA-2 and a method for detecting the islet cell antigen IA-2 in a sample.

REFERENCES:
patent: 5200318 (1993-04-01), Rabin et al.
patent: 5888813 (1999-03-01), Endl et al.
Ackermann et al., Biotechnology and Bioengineering. vol. 45, pp. 97-106, 1995.
Kohler., Science. vol. 233 pp. 1281-1286. 1986.
Steinunn Baekkeskov, et al., “Identification of the 64K Autoantigen in Insulin-Dependent Diabetes as the GABA-Synthesizing Enzyme Glutamic Acid Decarboxylase” Nature, vol. 347, Sep. 13, 1990 (p. 151-156).
Julia Dittler, et al., “GADIA2-Combi Determination as First-Line Screening for Improved Prediction of Type 1 Diabetes in Relatives” Diabetes, vol. 47, Apr. 1998 (4pgs).
Peter Ifversen, et al., “Effect of Cell-Derived Growth Factors and Cytokins on the Clonal Outgrowth of EBV-Infected B Cells and Established Lymphoblastoid Cell Lines” Hum. Antibod. Hybridomas, 1993, vol. 4, Jul. (pp. 115-123).
Anne-Marie Madec, et al., “Four IgG Anti-Islet Human Monoclonal Antibodies Isolated from a Type 1 Diabetes Patient Recognize Distinct Epitopes of Glutamic Acid Decarboxylase 65 and Are Somatically Mutated” GAD65-Driven Somatic Selection in an IDDM Patient (pp. 3541-3549).
Ahuva Nissim et al., “Antibody Fragments from a ‘Single Pot’ Phage Display Library as Immunochemical Reagents” The EMBO Journal vol. 13, No. 3, pp. 692-698, 1994.
Jerry P. Palmer, et al., “Insulin Antibodies in Insulin-Dependent Diabetics Before Insulin Treatment”, Science, vol. 222 (3pgs).
Mark A. Payton, et al., Realtionship of the 37,000- and 40,000-M, Tryptic Fragments of Islet Antigens in Insulin-Dependent Diabetes to the Protein Tyrosine Phosphatase-Like Molecule IA-2 (ICA512), Tyrosine Phospatases as Autoantigens in Type 1 Diabetes, (pp. 1506-1511).
Eric Peyron, et al., Human Monoclonal Autoantibodies Specific for the Bullous Pemphigoid Antigen 1 (BPAg1)1, The Journal of Immunology, 1994 (pp. 1333-1339).
Massimo Pietropaolo, et al., “Islet Cell Autoantigen 69 kD (ICA69)” Molecular Cloning and Characterization of a Novel Diabetes-Associated Autoantigen J. Clin. Invest. The American Society for Clinical Investigation, Inc., vol. 92, Jul. 1993, 359-371.
U. Roll, et al., “Combined Antibody Screening for Improved Prediction of IDDM- Modern Strategies” Exp. Clin. Endocrinol Diabetes 105 (1997) 1-14.
Michael Solimena, et al., “ICA 512, An Autoantigen of Type 1 Diabetes, Is An Intrinsic Membrane Protein of Neurosecretory Granules” The EMBO Journal vol. 15, No. 9, pp. 2102-2114, 1996.
Baowei Zhang, et al., “Autoantibodies to IA-2 in IDDM” Location of Major Antigenic Determinants, Diabetes, vol. 46, Jan. 1997 (pp. 40-43).

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