Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1984-06-01
1988-02-23
Kepplinger, Esther M.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435948, 4351722, 43524027, 530387, 436548, 935 99, 935110, G01N 5300, G01N 3353, C12N 500, A61K 3900
Patent
active
047270217
ABSTRACT:
Human monoclonal antibodies (HmAbs) capable of reacting with cytokeratin are disclosed. It has been found that HmAbs De8, M54, M307, Hull, C29, Hu22 and Pa24 may be used to detect these cytoskeletal proteins in various cells. By means of these HmAbs the embryological origin of cells may be determined. This information may be used to determine the possible tissue source of metastasized tumors and greatly affects the management of these cancers.
REFERENCES:
Cote et al., Proc. Natl. Acad. Sci. USA, vol. 80, pp. 2026-2030, Apr. 1983
Houghton et al., J. Exp. Med., vol. 158, pp. 53-65, Jul. 1983.
Moll et al., Cell, vol. 31, pp. 11-24, Nov. 1982.
Lane, J. Cell Biol, 92: 665-673 (1982).
Lane et al., Cold Spring Harbor Symp. Quant. Biol., 46: 387-402 (1981).
Cote Richard J.
Houghton Alan N.
Oettgen Herbert F.
Old Lloyd J.
Thomson Timothy M.
Foley Shawn P.
Kepplinger Esther M.
Sloan-Kettering Institute for Cancer Research
White John P.
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