Chemistry: analytical and immunological testing – Involving production or treatment of antibody – Monoclonal antibody
Patent
1983-03-09
1986-09-23
Warden, Robert J.
Chemistry: analytical and immunological testing
Involving production or treatment of antibody
Monoclonal antibody
435 7, 435 68, 4351722, 435240, 435241, 935 93, 935 95, 935 96, 935 99, 935100, 935106, 935108, 935110, C12N 1500, C12N 500, G01N 3353, C12P 2100
Patent
active
046135766
ABSTRACT:
Hybridomas which produce human monoclonal antibodies are disclosed. The hybridomas are formed by fusing lymphocytes from individuals with various cancers to an immortal cell line, such as a myeloma, from, e.g., a human cell line, or a mouse cell line.
REFERENCES:
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Olsson, et al., Human-Human Hybridomas Producing Monoclonal Antibodies of Predefined Antigenic Specificity, Proc. Natl. Acad. Sci., U.S.A., 77, No. 9 (Sep. 1980), pp. 5429-5431.
Croce, et al., Production of Human Hybridomas Secreting Antibodies to Measles Virus, Nature, vol. 288, (Dec. 4, 1980), pp. 488-489.
Nowinski, et al., Human Monoclonal Antibody Against Forssman Antigen, Science, vol. 210, (Oct. 31, 1980), pp. 537-539.
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Edwards, et al., A Human-Human Hybridoma System Based on a Fast-Growing Mutant of the ARH-77 Plasma Cell Leukemia-Derived Line, Eur. J. Immunol., 12, pp. 641-648 (1982).
Beattie, Jr. Edward J.
Cote Richard J.
Houghton Alan N.
Morrissey Donna M.
Oettgen Herbert F.
Krawczewicz L.
Sloan-Kettering Institute for Cancer Research
Warden Robert J.
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