Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2009-03-12
2011-12-20
Bristol, Lynn (Department: 1643)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C435S325000, C435S320100
Reexamination Certificate
active
08080646
ABSTRACT:
The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to the extracellular domain (ECD) of activin receptor-like kinase-1 (ALK-1) and that function to abrogate the ALK-1/TGF-beta-1/Smad1 signaling pathway. The invention also relates to heavy and light chain immunoglobulins derived from human anti-ALK-1 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-ALK-1 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.
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Amundson Karin Kristina
Bedian Vahe
Belouski Shelly Sims
Hu-Lowe Dana Dan
Jiang Xin
Amgen Fremont Inc.
Bristol Lynn
Gunnison Jane T.
Li Z. Ying
Pfizer Inc.
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