Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1994-06-21
1997-06-17
Scheiner, Toni R.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
53038815, 5303882, 530865, 530866, 530350, 530395, 536 2353, 536 241, 935 15, C07K 1618, C07K 1630
Patent
active
056398638
ABSTRACT:
The variable chains of two human monoclonal antibodies (HMAbs) of the IgM isotype are characterized by elucidation of cDNAs encoding those chains. The HMAbs are specific against cell cycle independent, glioma-associated antigen, and the antibodies do not recognize cultured normal human astrocytes. Immunoconjugates based on the sequences identified should target both proliferating and non-proliferating glioma cells in vivo, thus providing a valuable adjunctive therapy in the treatment of these tumors.
REFERENCES:
Hawkins et al (1992) British Medical Journal 305:1348-1352.
Dan et al (1992) J. Neurosurg. 76:660-669.
Dan et al (1995) 82: 475-480. (Mar. issue).
Roih (1991) "Essential Immunology", Blackwell Scientific Publications, Oxford, pp. 65-68 + 74.
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