Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Animal cell – per se – expressing immunoglobulin – antibody – or...
Patent
1998-07-01
1999-12-28
Stucker, Jeffrey
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Animal cell, per se, expressing immunoglobulin, antibody, or...
4241601, 4242081, 53038835, 435 71, C12N 500, A61K 3942, C07K 1600, G01N 3353
Patent
active
060080442
ABSTRACT:
A method for neutralizing the retrovirus Human Immunodeficiency Virus-1 (HIV-1) through free virus neutralization or fusion inhibition, comprises adding to a cell mixture of HIV-infected and uninfected cells, a neutralizing agent which specifically binds to at least a portion of the amino acid sequence R-Leu-Ile-Cys-R', where R is either absent or a sequence of 1 to 5 amino acids selected from the group consisting of Lys, Gly-Lys, Ser-Gly-Lys, Cys-Ser-Gly-Lys and Gly-Cys-Ser-Gly-Lys, and R' is either absent or a sequence of 1 to 2 amino acids selected from the group consisting of Thr and Thr-Thr, under conditions effective for allowing said neutralizing agent to inhibit fusion between said HIV-1 infected cells or free HIV-1 and said uninfected cells or administering the neutralizing agent orally, intravenously, or intramuscularly under conditions effective for allowing said neutralizing agent to inhibit fusion between HIV-1 infected cells and uninfected cells. In one embodiment, the neutralizing agent is a novel human monoclonal antibody.
REFERENCES:
patent: 4722888 (1988-02-01), Broder et al.
patent: 4755457 (1988-07-01), Robert-Guroff et al.
patent: 4761470 (1988-08-01), Emiri et al.
patent: 4798797 (1989-01-01), Montagnier et al.
patent: 4812556 (1989-03-01), Vahlne et al.
patent: 4833071 (1989-05-01), Wang et al.
patent: 4833072 (1989-05-01), Krchnak et al.
patent: 4839288 (1989-06-01), Montagnier et al.
patent: 5087557 (1992-02-01), McClure
Gorney, et al., "General of Human Monoclonal Antibodies to Human Immunodeficiency Virus", Proceedings of the National Academy of Science (U.S.A.) (1989) 86:1624-1628.
Kawamura, et al., Abstract No. Th.C.O.4, "A Hybridoma Producing Human Monoclonal IgG Neutralizes the HTL-IIIb Isolate In Vitro", V. International Conference on AIDS, p. 533, (1989).
Boyer, et al., Abstract No. T.C.P.59, "Characterization of Human Monoclonal Antibodies Against HIV-1 With Group Specific Neutralizing Activities", V. International Conference on AIDS (1989), p. 576.
Zolla-Pazner, et al., Abstract No. Th.C.O.10, "Biological Functions of Human Monoclonal Antibodies to HIV", V. International Conference on AIDS (1989), p. 534.
Pinter, et al., "Oligomeric Structure of gp41, the Transmembrane Protein of Human Immunodeficiency Virus Type 1", Journal of Virology (1989) 63:2674-2679.
Till, et al., "Human Immunodeficiency Virus-Infected T-Cells and Monocytes Are Killed by Monoclonal Human Anti-gp41 Antibodies Coupled to Ricin A Chain", Proceedings of the National Academy of Science (U.S.A.) (1989) 86:1987-1991.
Navia, et al., Abstract No. M.C.O.23 "Three Dimensional Structure of the HIV-1 Protease and Its Role In Virus Maturation", V. International Conference on AIDS (1989), p. 513.
DeBouck, et al., Abstract No. T.C.O.11 "Expression, Purification, Structure Activity and Substrate Specificity of the HIV-1 Retroviral Protease", V. International Conference on AIDS (1989), p. 517.
Tyler, et al., Abstract No. T.C.O.33 "Identification of Sites Within gp41 Which Serve as Targets for ADCC Using Human Monoclonal Antibodies", V. International Conference on AIDS (1989), p. 521.
Fauci, Anthony S., "The Human Immunodeficiency Virus: Infectivity and Mechanisms of Pathogenesis", Science (1988) 239:617-622.
Gallo, et al., "AIDS in 1988", Scientific American (1988) 259:41-48.
Robert-Guroff, et al., "Spectrum of HIV-1 Neutralizing Antibodies in a Cohort of Homosexual Men: Result of a 6 Year Prospective Study", AIDS Research in Human Retroviruses (1988) 4:343-350.
McPhee, et al., "Recognition of Envelope and TAT Protein Synthetic Peptide Analogs by HIV Positive Sera or Plasma", F.E.B. (1988) 233:393-396.
McPhee, et al., "Putative Contact Prototypes for HIV-1 Envelope Proteins gp120/gp41: Antiviral Action of Synthetic Peptide Analogs", Cold Spring Harbor Symposium (Sep. 1988), p. 17.
Jackson, et al., "Passive Immunoneutralisation of Human Immunodeficiency Virus in Patients With Advanced AIDS", Lancet (1988) 2:647-652.
Karpas, et al., "Effects of Passive Immunization in Patients With the Acquired Immunodeficiency Syndrome-Related Complex and Acquired Immunodeficiency Syndrome", Proceedings of the National Academy of Science (U.S.A.) (1988) 5:9234-9237.
Book entitled Anti-Idiotypes, Receptors, and Molecular Mimicry (1988) by D. Scott Linthicum and Nadir R. Farid.
Johnson, et al., "Site-Directed ELISA Identifies a Highly Antigenic Region of the Simian Immunodeficiency Virus Transmembrane Glycoprotein", AIDS Research and Human Retroviruses (1988) 4:159-164.
Kowalski, et al., "Functional Regions of the Envelope Glycoprotein of Human Immunodeficiency Virus Type 1", Science (1987) 237:1351-1355.
Matthews, et al., "Prospects for Development of a Vaccine Against HTLV-III Related Disorders", AIDS Research and Human Retroviruses (1987) 3:197-206.
Chiodi, et al., "Site-Directed ELISA With Synthetic Peptides Representing the HIV Transmembrane Glycoprotein", J. of Medical Virology (1987) 23:1-9.
Gnann, Jr., et al., "Synthetic Peptide Immunoassay Distinguishes HIV Type 1 and HIV Type 2 Infections", Science (1987) 237:1346-1349.
Franchini, et al., "Sequence of Simian Immunodeficiency Virus and Its Relationship to the Human Immunodeficiency Viruses", Nature (1987) 328:539-543.
Desrosiers, et al., "Animal Models for Acquired Immunodeficiency Syndrome", Reviews of Infectious Diseases (1987) 9:438-445.
Chakrabarti, et al., "Sequence of Simian Immunodeficiency Virus From Macaque and Its Relationship to Other Human and Simian Retroviruses", Nature (1987) 328:543-547.
Smith, et al., "Antibody to a Synthetic Oligopeptide in Subjects at Risk for Human Immunodeficiency Virus Infection", J. Clinical Microbiology (1987) 25:1498-1504.
Gnann, Jr., et al., "Diagnosis of AIDS by Using a 12-Amino Acid Peptide Representing an Immunodominant Epitope of the Human Immunodeficiency Virus", Journal of Infectious Diseases (1987) 156:261-267.
Norrby, et al., "Discrimination Between Antibodies to HIV and to Related Retroviruses Using Site-Directed Serology", Nature (1987) 329:248-250.
Gnann, Jr., et al., "Fine Mapping of an Immunodominant Domain in the Transmembrane Glycoprotein of Human Immunodeficiency Virus", Journal of Virology (1987) 61:2639-2641.
Banapour, et al., "Characterization and Epitope of a Human Monoclonal Antibody Reactive With the Envelope Glycoprotein of Human Immunodeficiency Virus", Journal of Immunology (1987) 139:4027-4033.
Modrow, et al., "Computer Assisted Analysis of Envelope Protein Sequences of Seven Human Immunodeficiency Virus Isolates: Prediction of Antigenic Epitopes in Conserved and Variable Regions", Journal of Virology (1987) 61:57-578.
The chapter "Use of Heteromyelomas in the Enhancement of Human Monoclonal Antibody Production", by Nelson H. Teng and Marcia Bieber from the book Methods of Hybridoma Formation (1987), pp. 257-271.
The chapter "Detection of Antibodies to HIV Using Synthetic Peptides Derived From the gp41 Envelope Protein", by Rosen, et al., from the book Vaccines 87 (1987), pp. 188-193.
Lifson, et al., "Induction of CD4-Dependent Cell Fusion by the HTLV-III/LAV Envelope Glycoprotein", Nature (1986) 322:725-728.
Rasheed, et al., "Virus-Neutralizing Activity, Serologic Heterogeneity, and Retrovirus Isolation From Homosexual Men In the Los Angeles Area", Virology (1986) 150:1-9.
Wang, et al., "Detection of Antibodies to Human T-Lymphotropic Virus Type III by Using a Synthetic Peptide of 21 Amino Acid Residues Corresponding to a Highly Antigenic Segment of gp41 Envelope Protein", Proceedings of the National Academy of Science (U.S.A.) (1986) 83:6159-6163.
Putney, et al., "HTLV-III/LAV-Neutralizing Antibodies to an E. Coli Produced Fragment of the Virus Envelope", Science (1986) 234:1392-1395.
Robert-Guroff, et al., "HTLV-III-Neutralizing Antibodies in Patients With AIDS and AIDS Related Complex", Nature (1985) 316:72-74.
Chang, et al., "Detection of Antibodies to Human T-Cell Lymphotropic Virus-III (HTLV-III) With An Immunoassay Employing a Recombinant Escherichia coli Derived Viral Antigenic Peptide", J. Bio/Technology (1985) 3:905-909.
Dalgleish, et al., "The CD4(T4) Antigen Is An E
BioClonetics
Park Hankyel T.
Stucker Jeffrey
LandOfFree
Human monoclonal antibodies directed against the transmembrane g does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Human monoclonal antibodies directed against the transmembrane g, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human monoclonal antibodies directed against the transmembrane g will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2381587