Human monoclonal antibodies directed against the transmembrane g

Details Human monoclonal antibodies directed against the transmembrane g Human monoclonal antibodies directed against the transmembrane g

1989-08-24

2000-07-04

Budens, Robert D.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Amino acid sequence disclosed in whole or in part; or...

4242081, 514 14, 514 15, 514 16, 530327, 530328, 530329, A61K 3921, C07K 706, C07K 708

Patent

active

060835044

ABSTRACT:
A method for neutralizing HIV-1 is disclosed. A preferred embodiment utilizes a novel human monoclonal antibody that binds to a conserved region of the gp41 transmembrane subunit of the virus. The antibody is produced by continuous cell lines developed using human B lymphocyte cells collected from a patient possessing high titers of anti-HIV antibodies. The conserved region bound by the neutralizing antibody is a peptide of approximately 12 amino acids in length. Similar regions on HIV-2 and SIV are also disclosed.

REFERENCES:
patent: 4629783 (1986-12-01), Cosand
patent: 4722888 (1988-02-01), Broder et al.
patent: 4755457 (1988-07-01), Robert-Guroff et al.
patent: 4798797 (1989-01-01), Montagnier et al.
patent: 4812556 (1989-03-01), Vahlne et al.
patent: 4833071 (1989-05-01), Wang et al.
patent: 4833072 (1989-05-01), Krchnak et al.
patent: 4839288 (1989-06-01), Montagnier et al.
Shafferman et al., Patterns of Antibody Recognition of Selected Conserved Amino Acid Sequences from the HIV Envelope in Sera from Different Stages of HIV Infection:, AIDS Research and Human Retroviruses (1989) 5:33-39.
Lambert et al., Abstract No. W.C.O.11 "Inhibitors of HIV-1 Protease Inhibit the Processing of GAG and GAG/POL Polyproteins in Infected T-Cells", V. International Conference on AIDS (1989), p. 526.
Emini et al., Abstract No. Th.C.O.30 "Neutralization of In Vivo HIV-1 Infectivity Mediated by In Vitro Neutralizing Antibody", V. International Conference on AIDS (1989), p. 538.
Gorny et al., "General of human monoclonal antibodies to human immuno-deficiency virus", Proceedings of the National Academy of Science (U.S.A.) (1989) 86:1624-1628.
Kawamura et al., Abstract No. Th.C.O.4, "A Hybridoma Producing Human Monoclonal IgG Neutralizes the HTLVIIIb Isolate In Vitro", V. International Conference on AIDS, p. 533.
Boyer et al., Abstract No. T.C.P.59, "Characterization of Human Monoclonal Antibodies Against HIV-1 with Group Specific Neutralizing Activities", V. International Conference on AIDS (1989), p. 576.
Zolla-Pazner et al., Abstract No. Th.C.O.10, "Biological Functions of Human Monoclonal Antibodies to HIV", V. International Conference on AIDS (1989), p. 534.
Pinter et al., "Oligomeric Structure of gp41, the Transmembrane Protein of Human Immunodeficiency Virus Type 1" Journal of Virology (1989) 63:2674-2679.
Till et al., "Human immunodeficiency virus-infected T-cells and monocytes are killed by monoclonal human anti-gp41 antibodies coupled to ricin A chain", Proceedings of the National Academy of Science (U.S.A.) (1989) 86:1987-1991.
Navia et al., Abstract No. M.C.O.23 "Three-dimensional Structure of the HIV-1 Protease and its Role in Virus Maturation", V. International Conference on AIDS (1989), p. 513.
Debouck et al., Abstract No. T.C.O.11 "Expression, Purification, Structure, Activity and Substrate Specificity of the HIV-1 Retroviral Protease", V. International Conference on AIDS (1989), p. 517.
Tyler et al., Abstract No. T.C.O.33 "Identification of Sites within gp41 which Serve as Targets for ADCC Using Human Monoclonal Antibodies", V. International Conference on AIDS (1989), p. 521.
Anthony S. Fauci, "The Human Immunodeficiency Virus: Infectivity and Mechanisms of Pathogenesis", Science (1988) 239:617-622.
Gallo et al., "Aids in 1988", Scientific American (1988) 259:41-48.
Robert-Guroff et al., "Spectrum of HIV-1 Neutralizing Antibodies in a Cohort of Homosexual Men: Result of a 6 Year Prospective Study", AIDS Research in Human Retroviruses (1988) 4:343-350.
McPhee et al., "Recognition of envelope and tat protein synthetic peptide analogs by HIV positive sera or plasma", F.E.B. (1988) 233:393-396.
McPhee et al., "Putative Contact Prototopes for HIV-1 Envelope Proteins gp120/gp41: Antiviral Action of Synthetic Peptide Analogs" from the Cold Spring Harbor Symposium (Sep. 1988), p. 17.
Jackson et al., "Passive Immunoneutralisation of Human Immunodeficiency Virus in Patients with Advanced AIDS", Lancet (1988) 2:647-652.
Karpas et al., "Effects of passive immunization in patients with the acquired immunodeficiency syndrome-related complex and acquired immunodeficiency syndrome", Proceedings of the National Academy of Science (U.S.A.) (1988) 5:9234-9237.
Book entitled Anti-Idiotypes, Receptors, and Molecuclar Mimicry (1988) by D. Scott Linthicum and Nadir R. Farid.
Johnson et al., "Site-Directed Elisa Identifies a Highly Antigenic Region of the Simian Immunodeficiency Virus Transmembrane Glycoprotein", AIDS Research and Human Retroviruses (1988) 4:159-164.
Kowalski et al., "Functional Regions of the Envelope Glycoprotein of Human Immunodeficiency Virus Type 1", Science (1987) 237:1351-1355.
Matthews et al., "Prospects for Development of a Vaccine Against HTLV-III-Related Disorders", AIDS Research and Human Retroviruses (1987) 3:197-206.
Chiodi et al., "Site-Directed Elisa with Synthetic Peptides Representing the HIV Transmembrane Glycoprotein", J. of Medical Virology (1987) 23:1-9.
Gnann, Jr. et al., "Synthetic Peptide Immunoassay Distinguished HIV Type 1 and HIV Type 2 Infections", Science (1987) 237:1346-1349.
Franchini et al., "Sequence of simian immunodeficiency virus and its relationship to the human immunodeficiency viruses", Nature (1987) 328:539-543.
Desrosiers et al., "Animal Models for Acquired Immunodeficiency Syndrome", Reviews of Infectious Diseases (1987) 9:438-445.
Chakrabarti et al., "Sequence of simian immunodeficiency virus from macaque and its relationship to other human and simian retroviruses", Nature (1987) 328:543-547.
R.S. Smith et al., "Antibody to a Synthetic Oligopeptide in Subjects at Risk for Human Immunodeficiency Virus Infection", J. Clinical Microbiology (1987) 25:1498-1504.
Gnann, Jr. et al., "Diagnosis of Aids by Using a 12-Amino Acid Peptide Representing an Immunodominant Epitope of the Human Immunodeficiency Virus", Journal of Infectious Diseases (1987) 156:261-267.
Norrby et al., "Discrimination between antibodies to HIV and to related retroviruses using site-directed serology", Nature (1987) 329:248-250.
Gnann, Jr. et al., "Fine Mapping of an Immunodominant Domain in the Transmembrane Glycoprotein of Human Immunodeficiency Virus", Journal of Virology (1987) 61:2639-2641.
Banapour et al., "Characterization and Epitope of a Human Monoclonal Antibody Reactive with the Envelope Glycoprotein of Human Immunodeficiency Virus", Journal of Immunology (1987) 139:4027-4033.
Modrow et al., "Computer-Assisted Analysis of Envelope Protein Sequences of Seven Human Immunodeficiency Virus Isolates: Prediction of Antigenic Epitopes in Conserved and Varible Regions", Journal of Virology (1987) 61:57-578.
The chapter "Use of Heteromyelomas in the Enhancement of Human Monoclonal Antibody Production" by Nelson H. Teng and Marcia Bieber from the book Methods of Hybridoma Formation (1987), pp. 257-271.
The chapter "Detection of Antibodies to HIV Using Synthetic Peptides Derived from the gp41 Envelope Protein", by Rosen et al., from the book Vaccines 87 (1987), pp. 188-193.
Lifson et al., "Induction of CD4-dependent cell fusion by the HTLV-III/LAV envelope glycoprotein", Nature (1986) 322:725-728.
Rasheed et al., "Virus-Neutralizing Activity, Serologic Heterogeneity, and Retrovirus Isolation from homosexual Men in the Los Angeles Area", Virology (1986) 150:1-9.
Wang et al., "Detection of antibodies to human T-lymphotropic virus type III by using a synthetic peptide of 21 amino acid residues corresponding to a highly antigenic segment of gp41 envelope protein", Proceedings of the National Academy of Science (U.S.A.) (1986) 83:6159-6163.
Putney et al., "HTLV-III/LAV-Neutralizing Antibodies to an E. coli-Produced Fragment of the Virus Envelope", Science (1986) 234:1392-1395.
Robert-Guroff et al., "HTLV-III-neutralizing antibodies in patients with AIDS and AIDS-related complex", Nature (1985) 316:72-74.
Chang et al., "Detection of Antibodies to Human T-Cell Lymphotropic Virus-III (HTLV-III) with an Immunoassay Employing a Recombinant Escherichia Coli-Derived Viral Antigenic Peptide", J. Bio/Technology (1985)
Dalgleish et al., "The CD4(T4) antigen is an essential component of the re

Affiliated with

Also associated with

Rating

Human monoclonal antibodies directed against the transmembrane g does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Human monoclonal antibodies directed against the transmembrane g, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human monoclonal antibodies directed against the transmembrane g will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1483452