Human monoclonal antibodies against interleukin 8 (IL-8)

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

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C530S388230

Reexamination Certificate

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07622559

ABSTRACT:
Isolated human monoclonal antibodies which bind to IL-8 (e.g., human IL-8) are disclosed. The human antibodies can be produced in a hybridoma, transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, hybridomas, and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.

REFERENCES:
patent: 5175384 (1992-12-01), Krimpenfort et al.
patent: 5204244 (1993-04-01), Fell et al.
patent: 5306627 (1994-04-01), Yamada et al.
patent: 5401643 (1995-03-01), Yamada et al.
patent: 5434340 (1995-07-01), Krimpenfort et al.
patent: 5440021 (1995-08-01), Chuntharapai et al.
patent: 5543503 (1996-08-01), Chuntharapai et al.
patent: 5552284 (1996-09-01), Lee et al.
patent: 5571702 (1996-11-01), Lee et al.
patent: 5633141 (1997-05-01), Lee et al.
patent: 5652338 (1997-07-01), Matsushima et al.
patent: 5677426 (1997-10-01), Fong et al.
patent: 5686070 (1997-11-01), Doerschuk et al.
patent: 5698196 (1997-12-01), Matsushima et al.
patent: 5702946 (1997-12-01), Doerschuk et al.
patent: 5707621 (1998-01-01), Matsushima
patent: 5707622 (1998-01-01), Fong et al.
patent: 5767063 (1998-06-01), Lee et al.
patent: 5769269 (1998-06-01), Peters
patent: 5776457 (1998-07-01), Lee et al.
patent: 5783415 (1998-07-01), Lee et al.
patent: 5831032 (1998-11-01), Schraufstatter et al.
patent: 5840856 (1998-11-01), Chuntharapai et al.
patent: 5856457 (1999-01-01), Lee et al.
patent: 5874080 (1999-02-01), Hebert et al.
patent: 5874543 (1999-02-01), Chuntharapai et al.
patent: 5892017 (1999-04-01), Lee et al.
patent: 5919896 (1999-07-01), Lee et al.
patent: 5922541 (1999-07-01), Lee et al.
patent: 5925352 (1999-07-01), Matsushima et al.
patent: 5939598 (1999-08-01), Kucherlapati et al.
patent: 6015557 (2000-01-01), Tobinick et al.
patent: 6075181 (2000-06-01), Kucherlapati et al.
patent: 6087475 (2000-07-01), Lee et al.
patent: 6114598 (2000-09-01), Kucherlapati et al.
patent: 6150584 (2000-11-01), Kucherlapati et al.
patent: 6162963 (2000-12-01), Kucherlapati et al.
patent: 6177077 (2001-01-01), Tobinick
patent: 6300129 (2001-10-01), Lonberg et al.
patent: 6376659 (2002-04-01), Matsushima et al.
patent: 6379660 (2002-04-01), Saavedra et al.
patent: 6419934 (2002-07-01), Tobinick
patent: 6419944 (2002-07-01), Tobinick
patent: 6423321 (2002-07-01), Tobinick
patent: 6428787 (2002-08-01), Tobinick
patent: 6436390 (2002-08-01), Tekamp-Olson et al.
patent: 6680209 (2004-01-01), Buechler et al.
patent: 6682736 (2004-01-01), Hanson et al.
patent: 7282568 (2007-10-01), Teeling et al.
patent: 2001/0006637 (2001-07-01), Akahoshi et al.
patent: 2002/0006405 (2002-01-01), Kitajima et al.
patent: 0315062 (1989-05-01), None
patent: 0955060 (1999-11-01), None
patent: 0966971 (1999-12-01), None
patent: 0991423 (2000-04-01), None
patent: WO-89/08665 (1989-09-01), None
patent: WO-89/10962 (1989-11-01), None
patent: WO-90/02178 (1990-03-01), None
patent: WO-90/04036 (1990-04-01), None
patent: WO-90/12878 (1990-11-01), None
patent: WO-91/00906 (1991-01-01), None
patent: WO-91/10741 (1991-07-01), None
patent: WO-92/03918 (1992-03-01), None
patent: WO-92/04372 (1992-03-01), None
patent: WO-92/17497 (1992-10-01), None
patent: WO-94/02602 (1994-02-01), None
patent: WO-94/25585 (1994-11-01), None
patent: WO-94/28931 (1994-12-01), None
patent: WO-95/23865 (1995-09-01), None
patent: WO-96/02576 (1996-02-01), None
patent: WO-96/22785 (1996-08-01), None
patent: WO-96/33735 (1996-10-01), None
patent: WO-97/01354 (1997-01-01), None
patent: WO-97/13852 (1997-04-01), None
patent: WO-97/39772 (1997-10-01), None
patent: WO-97/39775 (1997-10-01), None
patent: WO-97/49426 (1997-12-01), None
patent: WO-98/17312 (1998-04-01), None
patent: WO-98/24884 (1998-06-01), None
patent: WO-98/58671 (1998-12-01), None
patent: WO-00/50079 (2000-08-01), None
patent: WO-00/57902 (2000-10-01), None
patent: WO-01/25492 (2001-04-01), None
patent: WO-01/32879 (2001-05-01), None
patent: WO-01/40306 (2001-06-01), None
patent: WO-01/49321 (2001-07-01), None
patent: WO-01/57056 (2001-08-01), None
patent: WO-02/24217 (2002-03-01), None
Janeway et al. Immunobiology, 3rd Edition, Garlend Press, 1997, p. 3:7-3:11.
Rudikoff et al. PNAS, USA, 1982, 79(6):1979-1983.
Fundamental Immunology, William E. Paul, MD 3rdEd. 1993, p. 242.
Protolano et al., J. Immunol.,1993, vol. 150, p. 880-887.
Alt, Frederick W. et al., “Immunoglobulin genes in transgenic mice,”TIG, vol. 1:231-236 (1985).
Attwood, Teresa K., “The Babel of Bioinformatics,”Science, vol. 290:471-473 (2000).
Berman, Jeffrey E. et al., “Content and organization of the human Ig VHlocus: definition of three new VHfamilies and linkage to the Ig CHlocus,”The EMBO Journal, vol. 7(3):727-738 (1988).
Berton, Michael T. et al., “Synthesis of germ-line γ1 immunoglobulin heavy-chain transcripts in resting B cells: Induction by interleukin 4 and inhibition by interferon γ,”Proc. Natl. Acad. Sci. USA, vol. 86:2829-2833 (1989).
Bollag, Roni J. et al., “Homologous Recombination in Mammalian Cells,”Annu. Rev. Genet., vol. 23:199-225 (1989).
Brüggemann, Marianne et al., “A repertoire of monoclonal antibodies with human heavy chains from transgenic mice,”Proc. Natl. Acad. Sci. USA, vol. 86:6709-6713 (1989).
Brüggemann, Marianne et al., “Human antibody production in transgenic mice: expression from 100 kb of the human IgH locus.”Eur. J. Immunol., vol. 21:1323-1326 (1991).
Bucchini, D. et al., “Rearrangement of a chicken immunoglobulin gene occurs in the lymphoid lineage of transgenic mice,”Nature, vol. 326:409-411(1987).
Buttin, G., “Exogenous Ig gene rearrangement in transgenic mice: a new strategy for human monoclonal antibody production?”TIG, vol. 3(8):205-206 (1987).
Capecchi, Mario R., “Altering the Genome by Homologous Recombination,”Science, vol. 244:1288-1292 (1989).
Capecchi, Mario R., “The New Mouse Genetics: Altering the Genome by Gene Targeting,”TIG, vol. 5(3):70-76 (1989).
Chen, Pojen P. et al., “Characterization of Two Immunoglobulin VHGenes that are Homologous to Human Rheumatoid Factors,”Arthritis and Rheumatism, vol. 32(1):72-76 (1989).
Coffman, Robert L. et al., “A Mouse T Cell Product that Preferentially Enhances IgA Production, I. Biologic Characterization,”The Journal of Immunology, vol. 139(11):3685-3690 (1987).
Coffman, Robert L. et al., “A T Cell Activity that Enhances Polyclonal IgE Production and its Inhibition by Interferon-γ,”The Journal of Immunology, vol. 136(3):949-954 (1986).
Doetschman, Thomas et al., “Targetted correction of a mutant HPRT gene in mouse embryonic stem cells,”Nature, vol. 330:576-578 (1987).
Durdik, Jeannine et al., “Isotype switching by a microinjected μ immunoglobulin heavy chain gene in transgenic mice,”Proc. Natl. Acad. Sci. USA, vol. 86:2346-2350 (1989).
Esser, Charlotte et al., “Rapid induction of transcription of unrearranged sγ1 switch regions in activated murine B cells by interleukin 4,”The EMBO Journal, vol. 8(2):483-488 (1989).
Ferrier, Pierre et al., “Separate elements control DJ and VDJ rearrangement in a transgenic recombination substrate,”The EMBO Journal, vol. 9(1):117-125 (1990).
Fishwild, Dianne M. et al., “High-avidity human IgGκ monoclonal antibodies from a novel strain of minilocus transgenic mice,”Nature Biotechnology, vol. 14(7):845-851 (1996).
Forni, Luciana et al., “Extensive splenic B cell activation in IgM-transgenic mice,”Eur. J. Immunol., vol. 20:983-989 (1990).
Gerstein, Rachel M. et al., “Isotype Switching of an Immunoglobulin Heavy Chain Transgene Occurs by DNA Recombination between Different Chromosomes,”Cell, vol. 63:537-

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