Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2006-11-21
2006-11-21
Gambel, Phillip (Department: 1644)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S387300, C530S387900, C530S388100, C530S388200, C530S388220, C530S388700, C530S388800, C530S389700
Reexamination Certificate
active
07138496
ABSTRACT:
Compositions are provided that comprise antibody against membrane proteins such as chemokine receptors. In particular, monoclonal human antibodies against human CXCR4 are provided that are capable of inhibiting HIV infection and chemotaxis in human breast cancer cells. The antibodies can be used as prophylactics or therapeutics to prevent and treat HIV infection and cancer, for screening drugs, and for diagnosing diseases or conditions associated with interactions with chemokine receptors.
REFERENCES:
patent: 5994515 (1999-11-01), Hoxie
patent: WO 99/ 50461 (1999-03-01), None
patent: WO 01/79229 (2001-10-01), None
Lederman et al. Molecular Immunology 1991. 28: 1171-1181.
Li et al. PNAS 1980. 77: 3211-3214.
Hua Shaobing
Pauling Michelle Haynes
Zhu Li
Crowder Chun
Gambel Phillip
Genetastix Corporation
Wilson Sonsini Goodrich & Rosati
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