Human monoclonal antibodies against bacterial toxins

Details Human monoclonal antibodies against bacterial toxins Human monoclonal antibodies against bacterial toxins

1983-09-22

1987-08-25

Hazel, Blondel

Chemistry: molecular biology and microbiology

Spore forming or isolating process

4351722, 935 95, 935 96, 424 92, 530387, C12N 500, C12N 1500

Patent

active

046892990

ABSTRACT:
The production of stable hybrid cell lines that secrete human monoclonal antibodies against bacterial toxins by fusing post-immunization human peripheral blood lymphocytes with nonsecretor mouse myeloma cells is described. Using the method, protective monoclonal antibodies against tetanus toxin and diphtheria toxin were produced that bind tetanus toxin and diphtheria toxin in vitro, respectively, and prevent tetanus and diphtheria in vivo in animals, respectively.

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