Human monoclonal anti-rhesus (D) antibodies and cell lines produ

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof

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4241531, 4241731, 435337, 435343, 435346, 53038815, 5303887, A61K 39395, C12N 500, C07K 1600, C12P 2108

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active

058515240

ABSTRACT:
The invention relates to 2 human monoclonal antibodies of sub-classes IgG1 and IgG3, against the Rhesus D antigen and to a pharmaceutical composition containing a mixture of the said antibodies, more particularly intended for the prophylaxis of the haemolytic disease of the newborn. The invention also relates to the heterohybridoma cell lines that produce these antibodies, which are filed with the "Deutsche Sammlung von Mikroorganismen und Zellkulturen" under accession numbers DSM AC 2039 and DSM AC 2040.

REFERENCES:
patent: 4634664 (1987-01-01), Oestberg
patent: 5487891 (1996-01-01), Bradley et al.
McCann et al., J. Immunological Methods, 115 pp. 3-15 (1988).
Hadley et al., Immunology, 67, pp. 550-552 (1989).
Hughes-Jones, Blood Reviews, 3, pp. 53-58 (1989).
Kozbor et al. Immunol. Today vol. 4: 72-79, 1983.

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