Human Mob-5 (IL-24) receptors and uses thereof

Chemistry: molecular biology and microbiology – Vector – per se

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S325000, C514S012200, C514S002600, C530S350000

Reexamination Certificate

active

06902930

ABSTRACT:
The present invention provides the receptors for Mob-5 (IL-24). One of the Mob-5 receptors comprises IL-22R1 and IL-20R2. Another Mob-5 receptor comprises IL-20R1 and IL-22R2. The invention also provides methods of inhibiting the Mob-5 receptor as well as methods of detecting cancer by detecting the presence of the Mob-5 receptor.

REFERENCES:
patent: 5422264 (1995-06-01), Quaranta et al.
patent: 5945511 (1999-08-01), Lok et al.
patent: WO 95 11986 (1995-05-01), None
patent: WO 99 64576 (1999-12-01), None
DATABASE EMBL Sep. 11, 1997, “Rattus norvegicus c49a mRNA, complete cds” Database accession No. AF004774.
Database Swall Nov. 1, 1999 “C49a” Database accession No. 09WVP8.
DATABASE EMBL Dec. 31, 1995 “Human MDA-7 mRNA, complete cds” Database accession No. U16261.
Database Swall Nov. 1, 1997 “Interleukin-24 precursor (MDA-7)” Database accession No. Q13007.
Dumoutier et al., “Cutting Edge: STAT Activation By IL-19, IL-20 and mda-7 Through IL-20 Receptor Complexes of Two Types.”J. of Immunol167:3545-3549 (2001).
Dumoutier et al., “Human interleukin-10-related T cell-derived inducible factor: Molecular cloning and functional characterization as an hepatype-stimulating factor,”Proc. Acad. Sci. USA97(18):10144-10149 (Aug. 29, 2000).
Hakryul et al. “Cloning oncogenic Ras-regulated genes by differential display,”Methods(ORLANDO), 16(4):365-372 (Dec. 1998).
Jiang et al., “The melanoma differentiation associated gene mda-7 suppresses cancer cell growth.”Proc. Natl. Acad. Sci. USA93:9160-9165 (1996).
Jiang et al., “Subtraction hybridization identified a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progression.”Oncogene11:2477-2486 (1995).
Knappe et al., “Induction of a Novel Cellular Homolog of Interleukin-10, AK155, by Transformation of T Lymphocytes with Herpevirus Samimiri.”J. Virol.74(8):3881-3887 (Apr. 2000).
Kotenko et al., “Identification and functional characterization of a second chain of the interleukin-receptor complex.”EMBO J16(18)5894-5903 (1997).
Kotenko and Pestka,Oncogene19:2557-2565 (2000).
Kotenko et al., “Human cytomegalovirus harbors its own unique IL-10 homolog (cmvIL-10).”Proc. Natl. Acad. Sci. USA97(4):1695-1700 (Feb. 15, 2000).
Kotenko et al. “Identification of the Functional Interleukin-22 (IL-22) Receptor Complex.”J. Biol. Chem.276(4):2725-2732 (Jan. 26, 2001).
Liang and Pardee, “Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction.”Science257:967-971 (1992).
Liang et al., “Ras activation of novel genes: Mob-1 as a model.”Proc. Natl. Acad. Sci USA91:12515-12519 (Dec. 1994).
Liang et al., “Differential display using one-base anchored oligo-dT primer.”Nucl. Acids Res.22:5763-5764 (1994).
Liang, “Factors ensuring successful use of differential display.”Methods16:361-364 (1998).
Liu et al., “Expression Cloning and Characterizationof a Human IL-10 Receptor.”J. Immunol152;1821-1829 (1994).
McCarthy et al., “Rapid induction of heparin-binding epidermal growth factor/diphtheria toxin receptor expression by Raf and Ras oncogenes.”Genes Dev.9:1953-1964 (1995).
Moore et al., “Homology of cytokine synthesis inhibitory factor (IL-10) to Epstein-Barr virus gene BCRFI.”Science248:1230-1234 (1990).
Schaefer et al. “Cutting Edge: FISP (IL-4-Induced Secreted Protein), a Novel Cytokine-Like Molecule Secreted by Th2 Cells.”J. Cell immunol166:5859-5863 (2001).
Soo et al., “Cutaneous rat wounds express C49a, a novel gene with homology to human differentiation associated gene, Mda-7.”J. Cell. Biochem.74:1-10 (1999).
Tan et al., “Characterization of Recombinant Extracellular Domain of Human Interleukin-10 Receptor.”J. Biol. Chem.270:12906-12911 (May 26, 1995).
Wang et al., “IL-10 Inhibit Transcription of Cytokine Genes in Human Peripheral Blood Mononuclear Cells.”J. Immunol.153:811-816 (1994).
Xie et al., “Interleukin (IL)-22, a Novel Human Cyotkine That Signals through the Interferon Receptor-related proteins CRF2-4 and IL-22R.”J. Biol. Chem.275(40):31335-31339 (Oct. 6, 2000).
Zhang et al., “Identification of a Novel Ligand-Receptor Pair Constitutively Activated byrasOncogenes.” 275(32):24436-24443 (Aug. 11, 2000).
Zhang et al., “Identification of rCop-1, a New Member of Ccn Gene Family, as a Negative Regulator for Cell Transformation.” Mol. Cell. Biol. 18:6131-6141 (1998).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Human Mob-5 (IL-24) receptors and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Human Mob-5 (IL-24) receptors and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human Mob-5 (IL-24) receptors and uses thereof will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3488836

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.