Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2006-04-11
2006-04-11
Andres, Janet L. (Department: 1646)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C435S006120, C435S069100, C435S455000, C435S320100
Reexamination Certificate
active
07026452
ABSTRACT:
The invention of the present application provides an isolated and purified human mitochondrial protein comprising the amino acid sequence of SEQ ID NO: 2 or SEQ ID NO: 4, which is a novel human protein promoting aggregation and fusion of mitochondria. The present invention also provides a polynucleotide encoding such a mitochondrial protein, antibody against such a mitochondrial protein, and a proteoliposome composed of such a mitochondrial protein and lipid. Mitochondrial proteins are useful for clarifying causes of mitochondrial diseases as well as for developing preventive and therapeutic methods thereof. Furthermore, antibodies and probes derived from genes encoding such proteins are potentially useful materials for diagnosis of condition of mitochondria in particular diseases. Furthermore, proteoliposomes provide measures for specific transfer of foreign genes or drugs targeted toward mitochondria.
REFERENCES:
patent: 6127159 (2000-10-01), Fuller et al.
patent: 99/57132 (1999-11-01), None
patent: 01/25274 (2001-04-01), None
Bowie et al., Science 247:1306-1310, 1990.
Wells, Biochemistry 29:8509-8517, 1990.
Y. Inoki et al., “Proteoliposomes Colocalized with Endogenous Mitochondria in Mouse Fertilized Egg”, Biochemical and Biophysical Research Communications, vol. 278, No. 1, pp. 183-191, 2000 with two abstracts from National Library of Medicine and Ideal Library.
Ansger Satel et al., “Control of Mitochondrial Morphology by a Human Mitofusin”, Journal of Cell Science, vol. 114, No. 5, pp. 867-874, 2001.
Yingying Tang et al., “Maintenance of Human Rearranged Mitochondrial DNAs in Long-Term Cultured Transmitochondrial Cells Lines”, Molecular Biology of the Cell, vol. 11, No. 7, pp. 2349-2358, Jul. 2000.
Andres Janet L.
Chandra Gyan
Japan Science and Technology Corporation
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