Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Reexamination Certificate
2006-02-01
2008-03-11
Landsman, Robert (Department: 1646)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
C530S350000
Reexamination Certificate
active
07341740
ABSTRACT:
The invention of the present application provides an isolated and purified human mitochondrial protein comprising the amino acid sequence of SEQ ID NO: 2 or SEQ ID NO: 4, which is a novel human protein promoting aggregation and fusion of mitochondria. The present invention also provides a polynucleotide encoding such a mitochondrial protein, antibody against such a mitochondrial protein, and a proteoliposome composed of such a mitochondrial protein and lipid. Mitochondrial proteins are useful for clarifying causes of mitochondrial diseases as well as for developing preventive and therapeutic methods thereof. Furthermore, antibodies and probes derived from genes encoding such proteins are potentially useful materials for diagnosis of condition of mitochondria in particular diseases. Furthermore, proteoliposomes provide measures for specific transfer of foreign genes or drugs targeted toward mitochondria.
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Y. Inoki et al., “Proteoliposomes Colocalized with Endogenous Mitochondria in Mouse Fertilized Egg”, Biochemical and Biophysical Research Communications, vol. 278, No. 1, pp. 183-191, 2000 with two abstracts from National Library of medicine and Ideal Library.
Chandra Gyan
Japan Science and Technology Corporation
Landsman Robert
Wenderoth , Lind & Ponack, L.L.P.
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