Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1998-06-03
2000-12-05
Johnson, Nancy A.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
530358, 435 6, 435 71, 514 2, C07K 1447, C12Q 168, G01N 353, A61K 3817
Patent
active
061568791
ABSTRACT:
A protein consisting essentially of purified human minor vault protein p193 or purified biologically active variants thereof, or a combination of purified human minor vault protein p193 and biologically active variants thereof. Also, a polynucleotide molecule encoding a protein which consists essentially of human minor vault protein p193, or its complementary strands. Further, there is provided a method of diagnosing and a method of treating patients with multidrug resistant cancer.
REFERENCES:
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Kickhoefer, Valerie A. et al., "Vaults are the answer, what is the question?" trends in Cell Biology 6:174-178(1996).
Ruf, Armin et al., "Structure of the catalytic fragment of poly(ADP-ribose) polymerase from chicken," Proc. Natl. Acad. Sci. USA 93:7481-7485 (1996).
Scheffer, George L. et al., "The drug resistance-related protein LRP is the human major vault protein," Nature Medicine 1(6):578-582 (1995).
Simonin Frederic et al., "The Carboxyl-terminal Domain of Human Poly(ADP-ribose) Polymerase," The Journal of Biological Chemistry 268:(18):13454-13461 (1993).
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Inman, E.M. et al., "Targeted Degradation of the Vault RNA (vRNA) in vivo Using Antisense Oligodeoxynucleotides," Molecular Biology of the Cell, vol. 6, Suppl., p. 196a.
Izquierdo, M.A. et al., "Relationship of LRP-human major vault protein to in vitro and clinical resisttance to anticancer drugs," Cytotechnology, 19(3):191-197, 1996.
Kickhoefer, V.A. et al., "Multidrug resistant cancer cell lines contain elevated levels of vaults," Proceedings of the American Association for Cancer Research Annual Meeting, 38:252, 1997.
Kickhoefer, V.A. et al., "Vault Ribonucleoprotein Particles from Rat and Bullfrog Contain Related Small RNA That Is Transcribed by RNA Ploymerase III," The Journal of Biological Chemistry, 268(11):7868-7873, Apr. 15, 1993.
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Kickhoefer Valerie A.
Rome Leonard H.
Farah Daivd A.
Johnson Nancy A.
The Regents of the University of California
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