Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases
Reexamination Certificate
2005-10-11
2005-10-11
Saidha, Tekchand (Department: 1652)
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Hydrolases
C435S212000, C435S252300, C435S320100, C536S023200, C536S023600
Reexamination Certificate
active
06953577
ABSTRACT:
Methionine aminopeptidases catalyse the co-translational removal of amino terminal methionine residues from nascent polypeptide chains. A newly-discovered enzyme, designated methionine aminopeptidase type-3 (MetAP-3), has a substrate specificity which is similar to MetAP-1 and MetAP-2, although it is not inhibited by fumagillin, an irreversible inhibitor of MetAP-2. MetAP-3 also preferentially localizes to mitochondria, unlike MetAP-1 and MetAP-2, which accumulate in the cytoplasm. One embodiment of the present invention relates to human cDNAs encoding polypeptides comprising MetAP-3. Other embodiments of the invention relate to nucleic acid molecules derived from these cDNAs, including complements, homologues, and fragments thereof, and methods of using these nucleic acid molecules, to generate polypeptides and fragments thereof. Other embodiments of the invention relate to antibodies directed against polypeptides comprising MetAP-3, and methods to screen for compounds or compositions that preferentially or specifically effect the activity of polypeptides comprising MetAP-3.
REFERENCES:
Sequence alignment between Accession No. T50575 and SEQ ID No: 8 [Redenbach et al. Mol. Microbiol. 21, 77-96 (1996)].
Aurora Rajeev
Dotson Stanton B.
Frazier Ronald B.
Sympson Carolyn J.
Woods Cynthia L.
Harness Dickey & Pierce PLC
Pharmacia Corporation
Saidha Tekchand
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