Human metabotropic glutamate receptor subtype mGluR7b

Details Human metabotropic glutamate receptor subtype mGluR7b Human metabotropic glutamate receptor subtype mGluR7b

2007-08-07

2007-08-07

Ulm, John (Department: 1649)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C536S023500, C435S007210, C435S069100, C435S252300, C435S320100

Reexamination Certificate

active

10331289

ABSTRACT:
The invention provides purified human metabotropic glutamate receptors, compositions comprising such receptors, and nucleic acids that encode such receptors.

REFERENCES:
patent: 3829583 (1974-08-01), Yuen
patent: 5202257 (1993-04-01), Heinemann et al.
patent: 5385831 (1995-01-01), Mulvihill et al.
patent: 5521297 (1996-05-01), Daggett et al.
patent: 5738999 (1998-04-01), Segerson et al.
patent: 0 568 384 (1993-04-01), None
patent: 0 569 240 (1993-05-01), None
patent: 0 574 257 (1993-06-01), None
patent: 0 711 832 (1996-05-01), None
patent: 91/06648 (1991-05-01), None
patent: 92/10583 (1992-06-01), None
patent: 93/24629 (1993-12-01), None
patent: 94/27602 (1994-12-01), None
patent: 94/29449 (1994-12-01), None
patent: 95/18154 (1995-07-01), None
patent: 95/22609 (1995-08-01), None
patent: 96/06167 (1996-02-01), None
Darnell et al., Molecular Cell Biology, Scientific American Books: New York, NY, pp. 233-235 (1986).
European Search Report for application EP 93 81 0663 mailed Mar. 29, 1994.
Flor et al., “Molecular Cloning, Functional Expression and Pharmacological Characterization of the Human Metabotropic Glutamate Receptor Type 2”, European J. of Neuroscience, 7:622-629 (1995).
Flor et al., “Molecular Cloning, Functional Expression and Pharmacological Characterization of the Human Metabotropic Glutamate Receptor Type 4”, Neuropharmacology, 34(2): 149-155 (1995).
Hollman et al., “Cloning by functional expression of a member of the glutamate receptor family”, Nature, 32:643-648 (1989).
Honoré, T., “Excitatory Amino Acid Receptor Subtypes and Specific Antagonists”, Medicinal Research Reviews, 9(1):1-23 (1989).
Knöpfel et al., “Metabotropic Glutamate Receptors: Novel Targets for Drug Development”, J. Medicinal Chemistry, 38(9):1417-1436 (1995).
Knöpfel et al., “Pharmacological Characterization of MCCG and MAP4 at the mGluR1b, MGluR2 and MGluR4A Human Metabotropic Glutamate Receptor Subtypes”, Neuropharmacology, 34(8):1099-1102 (1995).
Knöpfel et al., “Profiling of trans-azetidine-2,4-dicarboxylic acid at the human metabotropic glutamate receptors mGlu1b,-2,-4aand-5a”, European J. of Pharmacology, 288:389-392 (1995).
Masu et al., “Sequence and expression of a metabotropic glutamate receptor”, Nature, 349: 760-765 (1991).
Nakajima et al., “Direct Linkage of Three Tachykinin Receptors to Stimulation of Both Phosphatidylinositol Hydrolysis and Cyclic AMP Cascades in Transfected Chinese Hamster Ovary Cells”, J. of Biol. Chem., 267(4):2437-2442 (1992).
Nakakima et al., “molecular Characterization of a Novel Retinal Metabotropic Glutamate Receptor mGluR6 with a High Agonist Selectivity for L-2-Amino-4-phosphonobutyrate”, J. Biol. Chem., 268:11868-11873 (1993).
Nakanishi, S., “Molecular Diversity of Glutamate Receptors and Implications for Brain Function”, Science, 258:597-603 (1992).
Okamoto et al., “Molecular Characterization of a New Metabotropic Glutamate Receptor mGluR7 Coupled to Inhibitry Cyclic AMP Signal Transduction”, J. Biol. Chem., 269:1231-1236 (1994).
Pin et al., “Alternative splicing generates metabotropic glutamate receptors inducing different patterns of calcium release in Xenopus oocytes”, Proc. Natl. Acad. Sci., 89:10331-10335 (1992).
Pin et al., “Domains involved in the specificity of G protein activation in phospholipase C-coupled metabotropic glutamate receptors”, EMBO J., 13(2):342-348 (1994).
Prickett et al., A Calcium-dependent Antibody of Identification and Purification of Recombinant Proteins, BioTechniques, 7(6):580-589.
Probst et al., Sequence alignment of the G-protein coupled receptor superfamily, DNA and Cell Biology, 11(1):1-20.
Search Report for application No. GB 9416553.7 dated Nov. 28, 1994.
Stratagene Catalogue, 1991, p. 66.
Sugiyama et al., “A new type of glutamate receptor linked to inositol phospholipid metabolism”, Nature 325:531-533 (1987).
Tanabe et al., “A Family of Metabotropic Glutamate Receptors”, Neuron 8:169-179 (1992).
Tanabe et al., “Signal Transduction, Pharmacological Properties, and Expression Patterns of Two Rat Metabotropic Glutamate Receptors, GluR3 and MGluR4”, J. Neuroscience, 13(4):1372-1378 (1993).
Tanabe, Y. et al., “A family of metabotropic glutamate receptors—Rat metabotropic glutamate receptor 4 mRNA, primary transcript,”(Apr. 25, 1992); [XP002191416 Database EMBL Sequence Libhrary], [accession No. M92077].
Tanabe, Y. et al., “A family of metabotropic glutamate receptors—metabotropic glutamate receptor 4 precursor,” (Jul. 1, 1993); [XP002191417 Database Swiss-Prot Database], [Accession No. P31423].
Partial EPO Search Report for PCT/EP94/02991, Sep. 7, 1994.
Grynkiewisz et al., “A New Generation of Ca 2+ Indicators with Greatly Improved Fluorescence Properties”, Journal of Biological Chemistry, vol. 260, No. 6, pp. 3440-3450, (1985).
Nakajima et al., “Direct Linkage of Three Tachykinin Receptors to Stimulation of Both Phosphatidylinositol Hydrolysis and Cyclic AMP Cascades in Transfected Chinese Hamster Ovary Cells”, The Journal of Biological Chemistry, vol. 267, No. 4, pp. 2437-2442, (1992).
Makajima-Shimada et al., “Monitoring of intracellular calcium in Saccharomyces cerevisiae with an apoaequorin cDNA expression system”, Proc. Natl. Acad. Sci, vol. 88, pp. 6878-6882, (1991).
Flor et al., “A Novel Splice Variant of a Metabotropic Glutamate Receptor, Human mGluR7b”, Neuropharmacology, vol. 36, No. 2, pp. 153-159, (1997).
Weng et al., “Functional Coupling of a Human Retinal Metabotropic Glutamate Receptor (hmGluR6) to Bovine Rod Transducin and Rat G o in an in Vitro Reconstitution system”, The Journal of Biological Chemistry, vol. 272, No. 52, pp. 33100-33104, (1997).
Abe et al., “Molecular Characterization of a Novel Metabotropic Glutamate Receptor mGluR5 Cou0pled to Inositol Phosphate/Ca 2+ Signal Transduction”, The Journal of Biological Chemistry, vol. 267, No. 19, pp. 13361-13368, (1992).
Aramori et al., “Signal Transduction and Pharacological Characteristics of a Metabotropic Glutamate Receptor, mGluR1, in Transfected CHO Cells”, Neuron, vol. 8, pp. 757-765, (1992).
Chomczynski Piotr et al., “Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate-Phenol-Chloroform Extraction”, Analytical Biochemistry, vol. 162, pp. 156-159, (1987).
Ito Seiji et al., “Characterization of Prostaglandin E2-Induced Ca2+ Mobilization in Single Bovine Adrenal Chromaffin Cells by Digital Image Microscopy”, Journal of Neurochemistry, vol. 56, pp. 531-540, (1991).
Felder Christian C. et al., “A Transfected m1 Muscarinic Acetylcholine Receptor Stimulates Adenylate Cyclase via Phosphatidylinositol Hydrolysis”, Journal of Biological Chemistry, vol. 264, No. 34, pp. 20356-20362, (1989).
Guan KunLiang et al., “Eukaryotic Proteins Expressed inEscherichia coli: An Improved Thrombin Cleavage and Purification Procedure of Fusion Proteins with Gluthathione S-Transferase”, Analytical Biochemistry, vol. 192, pp. 262-267, (1991).
Nature, vol. 315, pp. 680-683, (1985).
Pin Jean-Philippe et al., “Alternative splicing generates metabotropic glutamate receptors inducing different patterns of calcium release in Xenopus oocytes”, Proc. Natl. Acad. Sci., USA, vol. 89, pp. 10331-10335, (1992).
Southern P. J. et al., “Transformation of Mammalian Cells to Antibiotic Resistance with a Bacterial Gene Under Control of the SV40 Early Region Promoter”, Journal of Molecular and Applied Genetics, vol. 1, pp. 327-341, (1982).
Steiner Alton L. et al., “Radioimmunoassay for Cyclic Nucleotides”, The Journal of Biological Chemistry, vol. 247, pp. 1106-1113, (1972).
Tanabe Yasuto et al., “A Family of Metabotropic Glutamate Receptors”, Neuron, vol. 8, pp. 169-179, (199

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