Human metabotropic glutamate receptor

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

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C536S023400, C435S069100, C435S007100

Reexamination Certificate

active

10346241

ABSTRACT:
A novel human metabotropic glutamate receptor (mGluR) protein is identified, sequenced, and cloned. The receptor may be used to screen for compounds that modulate the activity of the mGluR. The recombinant mGluR, as well as compounds that modulate mGluR activity, may be used in the diagnosis and treatment of neurological disorders and diseases.

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Aida et al. Molecular cloning of a putative Ca2+ sensing receptor cDNA from human kidney. Biochem. Biophys. Res. Commun., 1995, 214:524-529.
Jonathan A. Javitch et al., “A Cysteine Residue in the Third Membrane-Spanning Segment of the Human D2Dopamine Receptor is Exposed in the Binding-Site Crevice,” Proc. Nat'l. Acad. Sci. USA 91, vol. 91, pp. 10355-10359, Oct. 1994.

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