Drug – bio-affecting and body treating compositions – Extract – body fluid – or cellular material of undetermined... – Hemic or immune system
Reexamination Certificate
2005-08-30
2005-08-30
Chan, Christina (Department: 1644)
Drug, bio-affecting and body treating compositions
Extract, body fluid, or cellular material of undetermined...
Hemic or immune system
C435S372000, C435S383000
Reexamination Certificate
active
06936281
ABSTRACT:
There is provided an isolated pluri-differentiated human mesenchymal progenitor cells (MPCs), a method for isolating and purifying human mesenchymal progenitor cells from Dexter-type cultures, and characterization of and uses, particularly therapeutic uses for such cells. Specifically, there is provided isolated MPCs which can be used for diagnostic purposes, to enhance the engraftment of hematopoietic progenitor cells, enhance bone marrow transplantation, or aid in the treatment or prevention of graft versus host disease.
REFERENCES:
patent: 5226914 (1993-07-01), Caplan et al.
patent: 5486359 (1996-01-01), Caplan et al.
patent: 5521067 (1996-05-01), Seshi
patent: 5733542 (1998-03-01), Haynesworth et al.
patent: 5811094 (1998-09-01), Caplan et al.
patent: 5942225 (1999-08-01), Bruder et al.
patent: 6010696 (2000-01-01), Caplan et al.
patent: 6149902 (2000-11-01), Artavanis-Tsakonas et al.
patent: WO 01/94541 (2001-12-01), None
patent: WO 03/029432 (2003-04-01), None
Dictionary of Cell Biology ed. Lackie et al, 1989, Academic Press, Harcourt Brace Jovanovich, p. 189.
Pittenger et al. Science. 1999. vol. 284, pp. 143-147.
Ager et al. Immune Receptor Supplement. Immunology Today. 1997. pp. 1-35.
Bordignon et al. Haematologica. 1999.vol. 84, pp. 1110-1149.
Seshi, B. “Proteomics knocks on hematology's door”Blood, May 2004, 103(10):3607.
Lazarus, H.M. et al. “Human bone marrow-derived mesenchymal (stromal) progenitor cells (MPCs) cannot be recovered from peripheral blood progenitor cell collections”J. Hemototherapy, 1997, 6:447-455.
Simmons, P.J. et al. “Isolation, characterization and functional activity of human marrow stromal progenitors in hemopoiesis”Advances in Bone Marrow Purging and Processing, 1994, 389:271-280.
Sullivan, A.K. et al. “Cellular composition of rat bone marrow stroma”Lab. Invest., 1989, 60(4):667-676.
Dexter, T.M. et al. “conditions Controlling the Proliferation of Haemopoietic Stem Cells In Vitro”J. Cell. Physiol., 1977, 91(3):335-344.
Greenberger, J.S. “Sensitivity of corticosteroid-dependent insulin-resistant lipogenesis in marrow preadipocytes of obese-diabetic (db/db) mice”Nature, Oct. 26, 1978, 275:752-754.
Seshi, B. et al. “Human Bone Marrow Stromal Cell: Coexpression of Markers Specific for Multiple Mesenchymal Cell Lineages”Blood Cells, Molecules, and Diseases, Jun. 2000, 26(3):234-246.
Seshi, B. “Discovery of Novel Hematopoietic Cell Adhesion Molecules From Human Bone Marrow Stromal Cell Membrane Protein Extracts by a New Cell-Blotting Technique”Blood, May 1994, 83(9):2399-2409.
Bordignon, C. et al. “Cell Therapy: Achievements and Perspectives”Haematologica, 1999, 84:1110-1149.
Gartner, S. and H.S. Kaplan “Long-term culture of human bone marrow cells”Proc. Natl. Acad. Sci. USA, Aug. 1980, 77(8):4756-4759.
Dexter, T.M. et al. “Long-Term Marrow Culture: An Overview of Techniques and Experience” in Long-TermBone Marrow Culture, Wright, D.G. et al., Eds., 1984, pp. 57-96.
Marini, F. et al. “Mesenchymal Stem Cells (MSC) from Patients with Chronic Myelogenous Leukemia (CML) Patients can be Transduced with Common Gene Transfer Vectors at High Efficiency, and are Genotypically Normal” Abstract from American Society of Hematology 42ndAnnual Meeting, Part 1, Dec. 1-5, 2000. San Francisco, Ca.
Keating, A. et al. “Effect of Different Promoters on Expression of Genes Introduced into Hematopoietic and Marrow Stromal Cells by Electroporation”Exp. Hematol., 1990, 18:99-102.
Chakrabarti, O. and S. Krishna “Molecular interactions of ‘high risk’ human papillomaviruses E6 and E7 oncoproteins: implications for tumour progression”J. Biosci., 2003, 28(3):337-348.
Charbord, P. et al. “Stromal cells from human long-term marrow cultures, but not cultured marrow fibroblasts, phagocytose horse serum constituents: studies with a monoclonal antibody that reacts with a species-specific epitope common to multiple horse serum proteins”Exp. Hematol., 1987, 15:72-77.
Conget, P.A. and J.J. Minguell “Phenotypical and functional properties of human bone marrow mesenchymal progenitor cells”J. Cell. Physiol., Oct. 1999, 181:67-73.
Dennis, J.E. et al. “A quadripotential mesenchymal progenitor cell isolated from the marrow of an adult mouse”J. Bone and Mineral Res., 1999, 14(5):700-709.
Deunsing, S. and K. Munger “The human papillomavirus type 16 E6 and E7 oncoproteins independently induce numerical and structural chromosome instability”Cancer Res., 2002, 62:7075-7082.
Deunsing, S. et al. “The human papillomavirus type 16 E6 and E7 oncoproteins cooperate to induce mitotic defects and genomic instability by uncoupling centrosome duplication from the cell division cycle”PNAS, 2000, 97(18):10002-10007.
Dorshkind, K. “Multilineage development from adult bone marrow cells”Nature Immunology, 2002, 3(4):311-313.
Durst, M. et al. “Inverse relationship between human papillomavirus (HPV) type 16 early gene expression and cell differentiation in nude mouse epithelial cysts and tumors induced by HPV-positive human cell lines”J. Virology, 1991, 65(2):796-804.
Friedenstein, A.J. et al. “Fibroblast precursors in normal and irradiated mouse hematopoietic organs”Exp. Hemat., 1976, 4:267-274.
Eaves, A.C. and C.J. Eaves “Maintenance and proliferation control of primitive hemopoietic progenitors in long-term cultures of human marrow cells”Blood Cells, 1988, 14:355-368.
Gerson, S.L. “Mesenchymal stem cells: No longer second class marrow citizens”Nature Med., 1999, 5(3):262-264.
Graf, L. et al. “Gene expression profiling of the functionally distinct human bone marrow stromal cell lines HS-5 and HS-27a”Blood, 2002, 100(4):1509-1511.
Gravitt, P. “HPV: The ultimate cancer initiator?”HPV Today, No. 3, Sep. 2003, pp. 1-4.
Haynesworth, S.E. et al. “Characterization of cells with osteogenic potential from human marrow”Bone, 1992, 13:81-88.
Haynesworth, S.E. et al. “Cell surface antigens on human marrow-derived mesenchymal cells are detected by monoclonal antibodies”Bone, 1992, 13:69-80.
Henderson, A.J. et al. “Functional characterization of two stromal cell lines that support B lymphopoiesis”J. Immunology, 1990, 145:423-428.
Hicok, K.C. et al. “Development and characterization of conditionally immortalized osteoblast precursor cell lines from human bone marrow stroma”J. Bone and Mineral Res., 1998, 13(2):205-217.
Horwitz, E.M. et al. “Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta”Nature Med., 1999, 5(3):309-313.
Iwata, M. et al. “Functional interleukin-7 receptors (IL7R) are expressed by marrow stromal cells: binding of IL-7 increases levels of IL-6 mRNA and secreted protein” Aug. 2002 (epub date May 2002), 100:1318-1325.
Keating, A. et al. “Donor origin of the in vitro haematopoietic microenvironment after marrow transplantation in man”Nature, 1982, 298:280-283.
Kelly, K.A. and J.M. Gimble “1,25-Dihydroxy vitamin D3inhibits adipocyte differentiation and gene expression in murine bone marrow stromal cell clones and primary cultures”Endocrinology, 1998, 139:2622-2628.
Koc, O.N. et al. “Bone marrow-derived mesenchymal stem cells remain host-derived despite successful hematopoietic engraftment after allogeneic transplantation in patients with lysosomal and peroxisomal storage diseases”Exp. Hematology, 1999, 27:1675-1681.
Kopen, G.C. et al. “Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains”Proc. Natl. Acad. Sci. USA, 1999, 96:10711-10716.
Liesveld, J.L. et al. “Characterization of human marrow stromal cells: Role in progenitor cell bi
Belyavskyi Michail A
Chan Christina
Saliwanchik Lloyd & Saliwanchik
University of South Florida
LandOfFree
Human mesenchymal progenitor cell does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Human mesenchymal progenitor cell, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human mesenchymal progenitor cell will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3465582