Human melanoma specific immunotoxins

Details Human melanoma specific immunotoxins Human melanoma specific immunotoxins

1984-09-25

1986-05-20

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Lymphokine

530391, 530413, 530387, A61K 39395, A61K 3944, C07K 1706

Patent

active

045900710

ABSTRACT:
Conjugates of monoclonal antibodies specific to human melanoma and the A chain of a toxic lectin such as ricin or an equivalent ribosomal inhibiting protein. The conjugate is synthesized by a novel process employing anti-toxic lectin B chain antibodies to remove lectin B chain impurities and provide a highly purified conjugate that is non-toxic to cells other than melanoma. The conjugates are used to treat human melanoma.
The hybridomas XMMME-001 and XMMME-002 were deposited with the American Type Culture Collection (A.T.C.C.) on Mar. 26, 1985, and given A.T.C.C. Accession Nos. HB8759 and HB8760, respectively.

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