Human MEKK proteins, corresponding nucleic acid molecules,...

Details Human MEKK proteins, corresponding nucleic acid molecules,... Human MEKK proteins, corresponding nucleic acid molecules,...

2005-12-13

2005-12-13

Monshipouri, Maryam (Department: 1652)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving transferase

C435S194000, C435S320100, C435S325000, C435S252300, C435S006120

Reexamination Certificate

active

06974677

ABSTRACT:
Isolated nucleic acid molecules encoding human MEKK proteins, and isolated MEKK proteins, are provided. The invention further provides antisense nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals carrying a human MEKK transgene. The invention further provides human MEKK fusion proteins and anti-human MEKK antibodies. Methods of using the human MEKK proteins and nucleic acid molecules of the invention are also disclosed, including methods for detecting human MEKK activity in a biological sample, methods of modulating human MEKK activity in a cell, and methods for identifying agents that modulate the activity of human MEKK.

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