Human map kinase homolog

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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536 235, 536 2431, 435 6, 435325, C07H 2104, C12Q 168, C12N 510

Patent

active

056633130

ABSTRACT:
The present invention provides nucleic acid and amino acid sequences that identify and encode a novel human map kinase homolog (SMAP) expressed in cells of the human stomach. The present invention also provides for PCR oligomers or hybridization probes for the detection of nucleotide sequences encoding SMAP or SMAP-like molecules, antisense molecules to the nucleotide sequences which encode SMAP, diagnostic tests based on SMAP encoding nucleic acid molecules, genetically engineered expression vectors and host cells for the production of purified SMAP, antibodies capable of binding specifically to SMAP, and agonists and inhibitors with specific binding activity for the polypeptide SMAP.

REFERENCES:
Davis, RJ, "MAPKs: new JNK expands the group" TIBS 19:470-473 (1994).
Derijard, et al., "Independent Human MAP Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms" Science 267:682-686 (1995).
Egan, SE and Weinberg, RA, "The pathway to signal achievement" Nature 365:781-783 (1993).
Han et al., "A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells" Science 265:808-811 (1994).
Lee et al., "A protein kinase involved in the regulation of inflammatory cytokine biosynthesis" Nature 372:739-745 (1994).

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