Human mannose-binding protein

Chemistry: molecular biology and microbiology – Spore forming or isolating process

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435 691, 4351723, 4353201, 4352351, 4352523, 43525233, 43525411, 4352542, 536 234, 536 235, 530350, 935 18, 935 27, 935 32, 935 34, 935 38, 935 55, 935 62, 935 70, 935 72, C12N 500, C12N 1500, C12N 700, C12N 121, C12N 116, C12N 118, C12P 2102, C12P 1934, C02K 300, C07H 1512

Patent

active

052701999

ABSTRACT:
Purified human mannose-binding protein and fragments thereof, nucleic acid producing these fragments, and vectors and cells including such nucleic acid are disclosed. The peptides and antibodies to those peptides are useful for diagnosis and treatment of disease.

REFERENCES:
patent: 4675382 (1987-06-01), Murphy
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Taylor et al., "Mammalian Mannose-Binding Proteins", Clinical Science, 70: 539-546 1986.
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Stahl et al., "Mannose-Specific Oligosaccharide Recognition by Mononuclear Phagocytes", Biol. Cell, 51: 215-218 1984.
Wild et al., "Isolation of Mannose-Binding Proteins from Human and Rat Liver", Biochem. J., 210: 167-174 1983.
Drickamer et al., "Mannose-Binding Proteins Isolated from Rat Liver Contain Carbohydrate-Recognition Domains Linked to Collagenous Tails", J. of Bio. Chemistry, 261: 6878-6887 1986.
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Drickamer et al., "Exon Structure of a Mannose-Binding Protein Gene Reflects Its Evolutionary Relationship to the Asialoglycoprotein Receptor and Nonfibrillar Collagens", J. of Bio. Chemistry, 262: 2582-2589 1987.
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Ezekowitz et al., "Abstract", Clinical Research, 35: p. 607A (1987).
Ezekowitz et al., "A Human Mannose-Binding Protein is an Acute-Phase Reactant That Shares Sequence Homology With Other Vertebrate Lectins", J. Exp. Med., 167: 1034-1046 1988.
Kuhlman et al., "The Human Mannose-Binding Protein Functions as an Opsonin", J. of Exp. Med., 169: 1733-1745.
Horwitz, "The Role of Human Mannose-Lectin-like Molecules in Host Defense", Bacteria-Host Cell Interaction, pp. 213-223 1988.

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