Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Oxidoreductase
Patent
1995-03-30
1996-12-31
Patterson, Jr., Charles L.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Oxidoreductase
4353201, 4352542, C12N 902
Patent
active
055893716
ABSTRACT:
The present invention relates to a method of preparing human Mn-superoxide dismutase (hMn-SOD) by genetic engineering, the DNA sequences which code for this enzyme, suitable vectors which contain these DNA sequences and host cells which can express these DNA sequences, and the enzyme hMn-SOD itself. Suggestions as to the use of this enzyme are also described.
REFERENCES:
patent: 3920521 (1975-11-01), Michelson et al.
patent: 3997402 (1976-12-01), Michelson
patent: 4029819 (1977-06-01), Michelson
patent: 4751180 (1988-06-01), Cousens et al.
patent: 5066591 (1991-11-01), Hallewell et al.
patent: 5115097 (1992-05-01), Uda et al.
patent: 5196335 (1993-03-01), Groner
patent: 5240847 (1993-08-01), Heckl et al.
patent: 5246847 (1993-09-01), Hartman et al.
patent: 5260204 (1993-11-01), Heckl et al.
patent: 5270195 (1993-12-01), Hartman et al.
patent: 5436162 (1995-07-01), Heckl et al.
Bannister and Bannister, "Isolation and Characterization of Superoxide Dismutase", Meth. Enzymol. 105:88-93 (1984).
Barra et al., "Primary Structure of Mangano Superoxide Dismutase from Human Liver", Oxyradicals and Their Scavenger Systems 1:336-339 (1983).
Barra et al., "The Primary Structure of Human Liver Manganese Superoxide Dismutase", J. Biol. Chem. 259(20):12595-12601 (1984).
Beck et al., "Human Mn Superoxide Dismutase cDNA Sequence", Nucl. Acids Res. 15(21):9076 (1987).
Bialy, "Recombinant Proteins: Virtual Reality", Bio/Technology 5:883-890 (1987).
Bridges et al., "Distribution of Iron-Containing Superoxide Dismutase in Vascular Plants", Plant Physiol. 68:275-278 (1981).
English abstract for German Patent Document No. DE 2 417 508 (1974).
Heckl, K., "Isolation of cDNAs Encoding Human Manganese Superoxide Dismutase", Nucl. Acids Res. 16:6224 (1988).
Ho et al., "Isolation and Characterization of Complementary DNAs Encoding Human Manganese-Containing Superoxide Dismutase", FEBS Letts. 229(2):256-260 (1988).
Jabusch et al., "Some Sulfhydryl Properties and Primary Structure of Human Erythrocyte Superoxide Dismutase", Biochemistry 19:2310-2316 (1980).
Jay et al., "Gene Expression: Chemical Synthesis of E. coli Ribosome Binding Sites and Their Use in Directing the Expression of Mammalian Proteins in Bacteria", Nucl. Acids Res. 10:6319-6329 (1982).
Kozak, M., "Possible Role of Flanking Nucleotides in Recognition of the AUG Initiator Codon by Eukaryotic Ribosomes", Nucl. Acids Res. 9(20):5233-5252 (1981).
Kozak, M., "Analysis of Ribosome Binding Sites from the s1 Message of Reovirus", J. Molec. Biol. 156:807-820 (1982).
Lehninger, A. L., Biochemistry, The Molecular Basis of Cell Structure and Function, 2nd Ed., New York: Worth Publishers, p. 149 (1975).
Marres et al., "Nucleotide Sequence Analysis of Nuclear Gene Coding for Manganese Superoxide Dismutase of Yeast Mitochondria, a Gene Previously Assumed to Code for the Rieske Iron-Sulphur Protein", Eur. J. Biochem. 147:153-161 (1985).
Nakagawa et al., "Enzymatic Cleavage of Amino Terminal Methionine From Recombinant Human Interleukin 2 and Growth Hormone by Aminopeptidase M", Bio/Technology 5:824-827 (1987).
Sharp et al., "Codon Usage in Yeast: Cluster Analysis CLearly Differentiates Highly and Lowly Expressed Genes", Nucl. Acids Res. 14(13):5125-5143 (1986).
Touati, D., "Cloning and Mapping of the Manganese Superoxide Dismutase Gene(sodA) of Escherichia coli K-12", J. Bacteriol. 155(3):1078-1087 (1983).
Urdea, M. S., et al., "Chemical Synthesis of a Gene for Human Epidermal Growth Factor Urogastrone and its Expression in Yeast", Proc. Natl. Acad. Sci. USA 80(24):7461-7465 (1983).
Hauptmann Rudolf
Heckl Konrad
Krystek Edeltraud
Maurer-Fogy Ingrid
Ostermann Elinborg
Boehringer Ingelheim International GmbH
Patterson Jr. Charles L.
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