Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Transferase other than ribonuclease
Patent
1998-02-25
1999-03-30
Hendricks, Keith D.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Transferase other than ribonuclease
4352523, 43525233, 43525411, 4352543, 435325, 435419, 4353201, 536 232, C12N 1554, C12N 910, C12N 1509
Patent
active
058887938
ABSTRACT:
The invention provides a human lysophosphatidic acid acyltranferase (HLPAAT) and polynucleotides which identify and encode HLPAAT. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of HLPAAT.
REFERENCES:
patent: 5563058 (1996-10-01), Davies et al.
GenBank Accession AF015811 "Mus musculus putative lysophosphatidic acid acyltransferase mRNA, complete cds" Submitted by Stamps et al., Aug. 7, 1997.
Kume K, et al. cDNA cloning and expression of murine 1-acyl-sn-glycerol-3-phosphate acyltransferase. Biochem Biophys Res Commun. 1997 Aug. 28; 237(3): 663-666.
Morand LZ, et al. Alteration of the fatty acid substrate specificity oflysophosphatidate acyltransferase by site-directed mutagenesis. Biochem Biophys Res Commun. 1998 Mar. 6; 244(1): 79-84.
Coleman J. Characterization of the Escherichia coli gene for 1-acyl-sn-glycerol-3-phosphate acyltransferase (plsC). Mol Gen Genet. 1992 Mar. 1; 232(2): 295-303.
Moolenaar WH. Lysophosphatidic acid, a multifunctional phospholipid messenger. J Biol Chem. 1995 Jun. 2; 270(22): 12949-12952.
Bursten SL, et al. Interleukin-1 rapidly stimulates lysophosphatidate acyltransferase and phosphatidate phosphohydrolase activities in human mesangial cells. J Biol Chem. 1991 Nov. 5; 266(31): 20732-20743.
Miki Y, et al. Acyl-acceptor specificities of 1-acylglycerolphosphate acyltransferase and 1-acylglycerophosphorylcholine acyltransferase resolved from rat livermicrosomes. Eur J Biochem. 1977 Dec. 1; 81(3): 433-441.
Yamashita S, et al. Separation of 1-acylglycerolphosphate acyltransferase and 1-acylglycerolphosphorylcholine acyltransferase of rat liver microsomes. Proc Natl Acad Sci U S A. 1975 72(2): 600-603, Feb. 1, 1977.
Corley Neil C.
Guegler Karl J.
Hillman Jennifer L.
Yue Henry
Hendricks Keith D.
Incyte Pharmaceuticals Inc.
Mayhew Bradley S.
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