Human lymphotoxin

Details Human lymphotoxin Human lymphotoxin

1994-05-16

1998-07-07

Ulm, John

Drug, bio-affecting and body treating compositions

Lymphokine

530351, 435 695, 435 712, 4352523, 4353201, 514 2, 514 12, A61K 3819, C07K 1452

Patent

active

057764468

ABSTRACT:
Lymphotoxin-producing human T-cell hybridomas are incubated in a medium containing phorbol myristate acetate, concanavalin-A or a mixture thereof, the resulting cells are fractionated by sucrose density-gradient centrifugation method to isolate a messenger RNA in 12.6S to 14.6S fractions, and a gene containing a part encoding a polypeptide having a lymphotoxin-activity is prepared from the messenger RNA. The gene is represented by the base sequence of the Table 1 as herein given. Using the present gene, a new lymphotoxin having the amino acid sequence (I) or (II) as given herein can be obtained by genetic engineering technology.

REFERENCES:
patent: 4920196 (1990-04-01), Aggarwal

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