Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1987-02-06
1990-04-24
Draper, Garnette D.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
530412, 530415, 530416, 530417, 530418, 530419, 530422, 530827, 424 851, 514 2, 514 8, 514 21, 435 702, 435 704, 4352401, 4352402, C07G 700, A61K 4505, C12N 500
Patent
active
049201964
ABSTRACT:
Biologically active lymphotoxin polypeptide species, and derivatives, fragments, aggregates and pharmaceutically acceptable salts are provided. The lymphotoxins are substantially homogenous, and are formulated into pharmaceutical compositions. The lymphotoxins are purified to a specific activity of at least 10.sup.6 units/mg protein by using hydrophobic substances and/or immobilized lentil lectin, or with the use of other chromatographic processes such as ion exchange chromatography, HPLC or gel filtration.
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Adler Carolyn R.
Draper Garnette D.
Genentech Inc.
Hensley Max D.
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