Human lymphoid cells expressing human immunodeficiency virus env

Details Human lymphoid cells expressing human immunodeficiency virus env Human lymphoid cells expressing human immunodeficiency virus env

1993-10-08

1995-10-31

Nucker, Christine M.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

435 72, 435 691, 435 693, 435 703, 4351721, 4351723, 4352401, 435974, C12N 522

Patent

active

054628725

ABSTRACT:
The present invention provides mammalian cells modified to stably express at least the entire human immunodeficiency virus-1 envelope protein gp160. The invention provides a vaccine comprising the cells of the invention. The invention also provides methods for screening compounds for their ability to inhibit formation of syncytia between cells that express HIV-1 gp160 and cells that express CD4 comprising mixing cells of invention, cells that express CD4 on their surfaces, and a test compound for a length of time sufficient for syncytia to form; and then determining the amount of syncytia formation.

REFERENCES:
patent: 4910132 (1990-03-01), Knight et al.
Klein et al., Proc. Nat. Acad. Sci., 71:3283-3286 (1974), "Continuous Lymphoid Cell Lines With Characteristics of B Cells (Bone-Marrow-Derived), Lacking the Epstein-Barr Virus Genome and Derived from Three Human Lymphomas".
Ratner, et al., Nature, 313:277-284 (1985).
Sodroski, et al., Nature, 321:412-417 (1986).
Schnittman, et al., Journal of Immunology, 141:4181-4186 (1988).
Hay, et al., Eds., "American Type Culture Collection Catalogue of Cell Lines and Hybridomas", 6th Edition, p. 53 (1988).
Sodroski et al: Role of the HTLV-III/LAV envelope in syncytium formation & cytopathicity; Nature, vol. 322 pp. 470-474, 1986.

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