Human lymphoid cells expressing human immunodeficiency virus env

Details Human lymphoid cells expressing human immunodeficiency virus env Human lymphoid cells expressing human immunodeficiency virus env

1995-06-02

1996-12-03

Nucker, Christine M.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435 72, 435 721, 435 691, 435 693, 4352402, 435974, 530350, 530826, C12Q 170

Patent

active

055807208

ABSTRACT:
The present invention provides mammalian cells modified to stably express at least the entire human immunodeficiency virus-1 envelope protein gp160. The invention provides a vaccine comprising the cells of the invention. The invention also provides methods for screening compounds for their ability to inhibit formation of syncytia between cells that express HIV-1 gp160 and cells that express CD4 comprising mixing cells of invention, cells that express CD4 on their surfaces, and a test compound for a length of time sufficient for syncytia to form; and then determining the amount of syncytia formation.

REFERENCES:
patent: 4910132 (1990-03-01), Knight et al.
Sodroski et al, "Role of the HTLV-III/LAV Envelope in Syncytium Formation and Cytopathicity", Nature, vol. 322, pp. 470-474 (1986).

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